AI Article Synopsis
- The study aimed to identify factors linked to long-term quality of life (QOL) improvements in patients with drug-resistant MTLE-HS after epilepsy surgery.
- 72 patients were evaluated before and after surgery, with significant improvements observed in QOL scores, particularly in those with lower depressive symptoms post-surgery.
- The findings suggest that while surgical outcomes can enhance QOL, pre-surgical variables don't predict long-term improvements; instead, lower depressive symptoms are crucial for better outcomes.
Article Abstract
Objectives: To identify variables independently associated with a meaningful improvement in QOL long after surgical treatment of drug-resistant MTLE-HS patients.
Material & Methods: We prospectively evaluated 72 consecutive MTLE-HS surgically treated patients and analyzed pre and post-surgical variables independently associated with a meaningful improvement in QOL evaluated by the Quality of Life in Epilepsy-31 (QOLIE-31) overall score, and its domain scores determined at follow-up after 36 to 131 months (mean 93 months) after surgery.
Results: The mean overall QOLIE-31 score and its subdomain scores improved significantly after surgery (p < 0.01), and 55 patients (76.4%) had a meaningful QOL improvement. Being seizure-free (Engel IA) after surgery showed a non-significant association (OR 2.63, CI 95% 0.53 to 13.05, p = 0.23) and lower depressive symptoms a significant association (OR 4.15, CI 95% 1.19 to 14.53, p = 0.03) with meaningful improvement of QOL.
Conclusions: Patients with MTLE-HS who underwent epilepsy surgery show a sustained, meaningful improvement in their QOL. Pre-surgical variables do not predict long-term QOL improvement after surgery. Lower levels of depressive symptoms at postoperative evaluation are associated with meaningful QOL improvement.
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| http://dx.doi.org/10.1111/ane.13406 | DOI Listing |
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