AI Article Synopsis
- Myeloproliferative neoplasm-unclassifiable (MPN-U) is a type of blood cancer that shows specific features resembling other blood disorders but does not fully fit those diagnoses.
- A study involving 1512 patients found that 82 had MPN-U, with common symptoms including high lactate dehydrogenase levels, elevated platelet counts, and abnormal megakaryocytes in biopsies.
- Thrombosis occurred in 21% of cases, and patients with lower platelet counts or high white blood cell counts at the start had reduced event-free survival, showing a need for developing prognostic scoring systems for MPN-U.
Article Abstract
Myeloproliferative neoplasm-unclassifiable (MPN-U) presents an MPN-type phenotype that fails to meet diagnostic criteria for other MPN variants. Variability in the clinicopathological phenotypes presents many challenges. Amongst a registry cohort of 1512 patients with MPN, 82 with MPN-U were included, with a median (range) age of 49·7 (13-79) years. Albeit heterogeneous, common presentation features included raised lactate dehydrogenase, thrombocytosis and clustered/pleomorphic megakaryocytes on trephine biopsy. Thrombosis was common (21%), necessitating vigilance. The median event-free survival was 11·25 years (95% confidence interval 9·3-not reached), significantly shortened in cases with lower platelet counts (<500 × 10 /l) and a leucocytosis (≥12 × 10 /l) at presentation. Generation of potential MPN-U prognostic scores is required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/bjh.17375 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!