Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, yet data regarding long-term ovarian reserve of female survivors are limited. The aim of this study was to investigate whether there is a differential pattern of anti-Mullerian hormone (AMH) levels in female childhood ALL survivors compared with the normal age-matched population. In a cohort of 56 female childhood ALL survivors (median age 29 years; median follow-up 20.6 years), a negative correlation was found between age at leukemia diagnosis and age-adjusted anti-Mullerian hormone (AMH) levels ( = -0.334,  = .031). Despite alkylating agent therapy, AMH levels did not differ significantly from age-related nomograms (age < 30,  = .17; age ≥ 30,  = .94). The mean number of children per fertile woman adjusted for maternal age was similar to the national average (2.76 versus 3.11,  = .19). Our results imply that reproductive outcomes are not significantly hampered in female pediatric ALL survivors. Long-term surveillance of ovarian reserve may enable personalized survivorship counseling.

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http://dx.doi.org/10.1080/10428194.2021.1901093DOI Listing

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