Introduction: As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (Q) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand.
Methods: Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, Q, n = 39252, age 0 to 95). In the population-based study, Q and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, Q and NfL sex differences were tested in relation to age.
Results: Men had higher Q and NfL concentrations and had higher Q and NfL concentrations from adolescence throughout life. NfL was not related to WML, but Q correlated positively with WMLs.
Discussion: The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.
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| http://dx.doi.org/10.1002/dad2.12141 | DOI Listing |
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