AI Article Synopsis
- Some medical treatments for rare conditions, like liver transplants, don't always have specific studies to guide doctors, so they often rely on expert opinions for better care.
- A new method called © helps create these guidance recommendations by combining existing guidelines, expert agreement, and understanding the challenges doctors face in following them.
- This approach includes input from everyone involved, like patients and caregivers, to ensure the recommendations are helpful and can be put into practice more easily.
Article Abstract
Background: Most interventions for conditions with a small cohort size, such as transplantation, are unlikely to be part of a clinical trial. When condition-specific evidence is lacking, expert consensus can offer more precise guidance to improve care. Management of cardiovascular risk in liver-transplant recipients is one example for which clinicians have, to date, adapted evidence-based guidelines from studies in the general population. However, even when consensus is achieved, implementation of practice guidance is often inadequate and protracted. We report on a novel mixed-methods approach, the ©, for the development of clinical-practice guidance when condition-specific evidence is lacking. We illustrate the method through the development of practice guidance for managing cardiovascular risk in liver-transplant recipients.
Methods: The © consists of (i) adaptation of relevant, existing, evidence-based clinical-practice guidelines for the target population; (ii) consensus by experts of the proposed practice guidance; (iii) identification of barriers to guidance adherence in current practice; and (iv) recommendation for implementation and dissemination of the practice guidance. The method is based on an iterative, user-centered approach in which the needs, wants, and limitations of all end users, including patients, are attended to at each stage of the design and development process.
Conclusions: © for clinical-practice-guidance development uses a mixed-methods approach to bring together broad representation from multiple disciplines and practice settings to develop consensus considering the unique needs and preferences of patients, caregivers, and practitioners who are directly impacted by clinical-practice-guidance recommendations. We hypothesize that a priori involvement of end users in the guidance-development process will lead to sustainable implementation of guidance statements into clinical practice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962731 | PMC |
| http://dx.doi.org/10.1093/gastro/goaa068 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electromechanics of the Molecule-Electrode Interface and Interface-Mediated Effects in Single-Molecule Junctions.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen 361005, China.
The molecule-electrode interface can regulate both the efficiency and pathways of electron transport through single-molecule junctions (SMJs). The electromechanics of the interface has proven crucial in exposing the underlying mechanisms of electron transmission through SMJs, providing a theoretical base and practical guidance for designing and constructing functional molecular devices. Here we encompass several currently developed methodologies for investigating the electromechanics of molecule-electrode interface and provide an account of their application in elucidating the effects of the molecule-electrode interface on electron transport properties of SMJs.
View Article and Find Full Text PDFImpact of fall ammonia fluctuations on winter nitrification in moving bed biofilm reactors.
Sci Total Environ
January 2025
Nexom, Winnipeg, Manitoba R2J 3R8, Canada.
This pilot-scale study investigated nitrifying moving bed biofilm reactors (MBBRs) in a post-lagoon treatment setup over two years to evaluate the impact of seasonal ammonia fluctuations on winter nitrification. In Year 2, reactors without fall ammonia starvation achieved significantly higher winter ammonia removal (97.2 ± 1.
View Article and Find Full Text PDFAssessment of residential renewable energy investment under dynamic market environment: Aspect from household benefits.
J Environ Manage
January 2025
Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa City, Kanagawa Prefecture, 252-0882, Japan. Electronic address:
The adoption of residential renewable energy is pivotal for achieving the 'Net Zero' goal, yet financial assessments of household investments in this area remain complex due to dynamic market conditions. This study introduces a novel closed-form financial valuation framework for residential solar photovoltaic (PV) systems, explicitly addressing the uncertainties of electricity market price fluctuations (market risk) and energy policy changes (policy risk) using Geometric Brownian Motion (GBM). A case study in France demonstrates the framework's application, revealing that the discount rate is the most influential factor in solar PV valuation, followed by system lifespan and policy-driven Feed-in Tariff (FiT) rates.
View Article and Find Full Text PDFReform of economic evaluation of medicines in Spain: proposals from the Advisory Committee for Pharmaceutical Financing.
Gac Sanit
January 2025
Pharmacy Service, Clínica Universidad de Navarra, Pamplona, Spain; Advisory Committee on the Financing of Pharmaceutical (CAPF), Spain.
This paper describes the reforms recommended by the Advisory Committee on the Financing of Pharmaceuticals (CAPF) for the National Health System (NHS) of Spain from 2019 to 2024 for the drug pricing and reimbursement process, to integrate economic evaluations and improve efficiency and sustainability. The CAPF has proposed a three-phase reform of the economic evaluation (EE) and budget impact analysis (BIA) processes. The first phase involves the mandatory submission of EE and BIA by applicants for new drugs.
View Article and Find Full Text PDFLeveraging Ergonomics and Human Factors (E/HF) for community impact: what have we learned about how to make a difference.
Ergonomics
January 2025
Department of Systems and Information Engineering, University of Virginia, Charlottesville, VA, USA.
Ergonomics and Human Factors (E/HF) practitioners are increasingly engaged in projects meant to centre underserved communities and reduce inequities. The subdiscipline of E/HF that has emerged to explore the application of E/HF in this way is called community ergonomics. In this qualitative-descriptive study, we reflect on the progress made in the field of community ergonomics since its original conceptualisation in 1994.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!