In the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chemoprophylaxis and in all of them several days had elapsed between onset of symptoms and diagnosis. The importance of information on malaria to tourists and physicians is stressed.
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The emergence of parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in fitness costs. This study investigates the gametocyte production and transmission fitness of African and Asian isolates with different K13 genotypes across multiple mosquito species.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Malaria Research and Training Center (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. To effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species.
View Article and Find Full Text PDFCurr Res Parasitol Vector Borne Dis
November 2024
Instituto de Investigaciones en Microbiología, Facultad de Ciencias, Universidad Nacional Autónoma de Honduras, Tegucigalpa, 11101, Honduras.
Malaria continues to be a major threat to public health in tropical regions, primarily affecting sub-Saharan Africa but also Asia, the Middle East, and Latin America. Malaria cases in Honduras have seen a significant decline and the country aims to eliminate the disease by 2030. This study examines the genetic diversity of and in Honduras using four molecular markers (, , , and ), and the chloroquine resistance marker in the context of the elimination phase.
View Article and Find Full Text PDFToxicol Rep
June 2025
Grupo Malaria, Universidad de Antioquia, Colombia.
Unlabelled: Hemozoin (HZ) is a waste product of hemoglobin digestion by and has been implicated in several pathological processes, including inflammation, oxidative stress, endothelial dysfunction, and immune dysregulation. Studying the effects of HZ on the human placenta is essential to understanding the impact of malaria infection during pregnancy. The present study explored the impact of HZ produced by and β-hematin, referred to here as natural HZ (nHZ) and synthetic HZ (sHZ), respectively, on human placental explants exposed .
View Article and Find Full Text PDFParasitol Int
January 2025
Malaria & Parasitic Emerging Diseases Laboratory, National Microbiology Center, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; Centro de Investigación Biomédica En Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Malaria remains a significant health threat in tropical and subtropical regions. The immune response to Plasmodium falciparum involves both humoral and cellular components, including phagocytosis by neutrophils. However, observing phagocytosis through light microscopy is uncommon.
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