Background: Data was mined with the help of an artificial intelligence system based on Python, data was collected, and a database was established using a Python crawler, and the relationship between the outcome of neurosurgery ICU patients and treatment using traditional Chinese medicine was ascertained through data management and statistical processing.
Method: The source data cases ( = 2237) were selected. By following the experimental design, data ( = 739) were obtained through artificial intelligence processing, including = 480 in the group with traditional Chinese medicine treatment and = 259 in the group without traditional Chinese medicine treatment. An evaluation was carried out using characteristics of patents' ICU stays and summated rating scales.
Results: There were statistical differences in 5 evaluation items ( < 0.05), and other comparison items also showed data with results favoring the outcomes in the intervention group using traditional Chinese medicine. . Traditional Chinese medicine as an alternative medical protocol effectively alleviates the stress and treatment fatigue brought about by modern medicine. Artificial intelligence data mining is a favorable medium to quantify this. Python will play a greater role in future clinical research because of its own characteristics.
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http://dx.doi.org/10.1155/2021/5548157 | DOI Listing |
Adv Sci (Weinh)
January 2025
State Key Laboratory of Advanced Drug Delivery and Release Systems, School of Pharmaceutical Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, P. R. China.
Mitochondrial quality control is paramount for cellular development, with mitochondrial electron flow (Mito-EF) playing a central role in maintaining mitochondrial homeostasis. However, unlike visible protein entities, which can be monitored through chemical biotechnology, regulating mitochondrial quality control by invisible entities such as Mito-EF has remained elusive. Here, a Mito-EF tracker (Mito-EFT) with a four-pronged probe design is presented to elucidate the dynamic mechanisms of Mito-EF's involvement in mitochondrial quality control.
View Article and Find Full Text PDFJ Speech Lang Hear Res
January 2025
Division of Speech and Hearing Sciences, The University of Hong Kong, China.
Purpose: Speech sound disorder (SSD) is one of the major speech disorders in school-age children. Given the heterogeneity in terms of subtypes within SSD, there is a need to develop techniques for a quick identification of these subtypes. Furthermore, given the paucity of studies from children with SSD from Cantonese-speaking homes and a noted prevalence of SSDs in Cantonese-speaking children, it becomes even more important to investigate the subtypes of SSDs in Cantonese-speaking children.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea.
Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Frontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of China, Qingdao/Sanya, 266003/572024, China.
The scarcity of effective neuroprotective agents and the presence of blood-brain barrier (BBB)-mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS-responsive borneol-based amphiphilic polymeric NPs are constructed by using traditional Chinese medicine borneol as functional blocks that served as surface brain-targeting ligand, inner hydrophobic core for efficient drug loading of membrane-permeable calcium chelator BAPTA-AM, and neuroprotective structural component. In MCAO mice, the nanoformulation (polymer: 3.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Pulmonary metastasis represents one of the most prevalent forms of metastasis in advanced melanoma, with mortality rates reaching 70%. Current treatments including chemotherapy, targeted therapy, and immunotherapy frequently exhibit limited efficacy or present high costs. To address these clinical needs, this study presents a biomimetic drug delivery system (Ce6-pTP-CsA) utilizing cryoshocked adipocytes (CsA) encapsulating the prodrug triptolide palmitate (pTP) and the photosensitizer Ce6, exploiting the characteristic of tumor cells to recruit and lipolyze adipocytes for energy.
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