Nanoemulsions are gaining importance in healthcare and cosmetics sectors as a result of the unique properties of nanosized droplets, such as high surface area. Here we review nanotechnology and nanoemulsions with focus on emulsifiers and nanoemulsifiers, and applications for drugs and vaccines delivery, cancer therapy, inflammation treatment, cosmetics, perfumes, polymers, and food. We discuss nanoemulsion safety and properties, e.g., stability, emulsification, solubility, molecular number and arrangements, ionic strength, pH and temperature.
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http://dx.doi.org/10.1007/s10311-021-01216-9 | DOI Listing |
J Therm Biol
December 2024
Department of Animal and Fish Production, Faculty of Agriculture, Alexandria University, Alexandria, 21545, Egypt.
Global warming is seriously threatening sheep farmings by increasing health problems and decreasing reproductive efficiency. In this study, pomegranate peels ethanolic extract (Ppee), rich in phenolic acids, was prepared in free (Fppee) and nanoemulsified (Nppee, with 18.49 nm-21.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Faculty of Health Sciences (FCS), University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
The repurposing of statins as neuroprotective agents and/or anti-brain tumor drugs is limited by challenges in brain bioavailability and systemic off-target effects. Therefore, improved and targeted delivery of statins to the brain is necessary. This study aimed to develop a high-strength liquid formulation of the poorly soluble prodrug simvastatin for intranasal administration, as a strategy to achieve high brain concentrations of the prodrug and/or its active form, tenivastatin.
View Article and Find Full Text PDFPhytomedicine
December 2024
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address:
Background: Gut dysbiosis, chronic diseases, and microbial recurrent infections concerns have driven the researchers to explore phytochemicals from medicinal and food homologous plants to modulate gut microbiota, mitigate diseases, and inhibit pathogens. Gingerols have attracted attention as therapeutic agents due to their diverse biological activities like gut microbiome regulation, gastro-protective, anti-inflammatory, anti-microbial, and anti-oxidative effects.
Purpose: This review aimed to summarize the gingerols health-promoting potential, specifically focusing on the regulation of gut microbiome, attenuation of disease symptoms, mechanisms of action, and signaling pathways involved.
Sci Rep
December 2024
Department of Pharmaceutical Science, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, 0204, South Africa.
Bedaquiline is a drug used for the treatment of multidrug-resistant TB in adults and children that is currently only commercially available in tablet form. The present study was aimed at preparing nanoemulsion (NE) of BDQ using natural vegetable oils to deliver BDQ. The optimisation of surfactant mixtures was undertaken using Design of Experiments (DoE), specifically an optimal mixture design.
View Article and Find Full Text PDFNanotechnol Sci Appl
December 2024
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Purpose: This study investigates the impact of various mixing parameters and surfactant combinations on the physical characteristics of nanoemulsions produced using high-speed homogenization. Nanoemulsions are explored for their capacity to enhance transdermal drug delivery in pharmaceutical and cosmetic contexts.
Methods: Employing a standard high-speed homogenizer typical in the cosmetic industry, we tested different combinations of Polysorbate (Tween®) and Sorbitan ester (Span®) surfactants under single and intermittent process configurations.
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