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Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study.
Am J Kidney Dis
December 2024
Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
Rationale & Objective: Afamin is a vitamin E-binding glycoprotein primarily expressed in liver and kidney. This study investigated whether serum afamin concentrations are associated with kidney function and incident kidney failure.
Study Design: Prospective cohort study with 6.
Clinical Spectrum and Prognosis of Atypical Autosomal Dominant Polycystic Kidney Disease Caused by Monoallelic Pathogenic Variants of IFT140.
Am J Kidney Dis
December 2024
Service de Néphrologie, Hémodialyse et Transplantation Rénale, Centre de référence MARHEA, CHRU Brest, Brest, France; Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Brussels, Belgium. Electronic address:
Rationale & Objective: Monoallelic predicted Loss-of-Function (pLoF) variants in IFT140 have recently been associated with an autosomal dominant polycystic kidney disease (ADPKD)-like phenotype. This study sought to enhance the characterization of this phenotype.
Study Design: Case series.
Glomerular Filtration of Creatinine: Validation of a Novel Index of Muscle Mass Among Older Adults.
Am J Kidney Dis
December 2024
Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
Rationale & Objective: Low muscle mass is common among older adults and associated with poor prognosis. Quantifying muscle mass is challenging in routine clinical practice. We hypothesized that glomerular filtration of creatinine (GFcr) reflects muscle mass, and previously proposed estimated GFcr (eGFcr), as a practical index of muscle mass in older adults.
View Article and Find Full Text PDFClinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study.
Am J Kidney Dis
December 2024
Transplantation Center, Seoul National University Hospital, Seoul, Korea. Electronic address:
Rationale & Objective: Recipients of kidney allografts are at risk for osteoporotic fractures (OF), but their association with patient and allograft outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure.
Study Design: A national retrospective cohort study.
Clinicopathologic, Proteomic and Outcome Characteristics of Renal Apolipoprotein C-II Amyloidosis: A Case Series.
Am J Kidney Dis
November 2024
Department of Laboratory Medicine and Pathology, Rochester, Minnesota. Electronic address:
Article Synopsis
- Amyloidosis derived from apolipoprotein C-II (AApoCII) is a rare condition that primarily affects the kidneys, presenting with symptoms like proteinuria and reduced kidney function, particularly in older patients.
- A study conducted with 25 cases from the Mayo Clinic revealed common histological characteristics, such as nodular amyloid deposits in glomeruli, and proteomic analysis identified specific Apo C-II variants in many patients.
- Despite significant kidney issues, including end-stage kidney disease in about half of the patients, the overall survival rate was more favorable, indicating potential for better outcomes in this condition.
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