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Extra-Axial Poorly Differentiated Chordoma Initially Misdiagnosed as Epithelioid Sarcoma.
Int J Surg Pathol
November 2024
Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Article Synopsis
- Poorly differentiated chordoma is a rare and aggressive type of tumor usually found in young patients, mainly at the skull base and cervical spine.
- A case study of a 60-year-old patient initially misdiagnosed with osteoarthritis revealed complex tumor characteristics that led to reconsideration of its diagnosis.
- The importance of accurate immunohistochemical testing, specifically for brachyury, is emphasized for correctly diagnosing this uncommon tumor and for understanding its unique molecular profile, which could aid in future analyses.
Combined microscopic transoral and endoscopic endonasal approach for a clival chordoma: A case report and literature review.
Surg Neurol Int
October 2024
Department of Neurosurgery, National Institute of Neurology and Neurosurgery, Tlalpan, Mexico.
Background: Chordomas are primary bone tumors derived from the embryonic notochord. They represent 1-4% of all malignant bone tumors. They have a predominantly extra-axial location, arising in the clival region in 35% of reported cases.
View Article and Find Full Text PDFPoorly differentiated extra-axial extraskeletal chordoma diagnosed by methylation profiling: case report and analysis of brachyury expression in SWI/SNF-deficient tumors.
Virchows Arch
April 2024
The Sikl Department of Pathology, Faculty of Medicine and University Hospital in Pilsen, Charles University, Prague, Czech Republic.
Article Synopsis
- Chordoma is a rare malignant tumor usually found in young patients, typically affecting the axial skeleton; this report focuses on a case involving a 74-year-old male with a high-grade tumor in the knee.
- Initial biopsies suggested metastatic clear-cell carcinoma, but imaging studies didn’t identify any primary tumors, leading to further investigation.
- Advanced molecular genetic analysis, including methylation profiling, identified the tumor as poorly differentiated chordoma, highlighting the importance of using comprehensive diagnostic tools for rare soft tissue tumors.
Intradural Chordoma Mimicking an Epidermoid Cyst on Imaging.
Cureus
June 2023
Radiology, Jichi Medical University, School of Medicine, Tochigi, JPN.
Chordomas are rare, locally aggressive, primary bone tumors derived from primitive notochord remnants. They almost always arise within the axial skeleton, particularly in the skull base and the sacrococcygeal region. They usually present as extradural tumors, but rarely, they present as entirely intradural tumors.
View Article and Find Full Text PDF[Primary extra-axial chordoma of femur: report of a case].
Zhonghua Bing Li Xue Za Zhi
January 2023
Department of Pathology, the People's Hospital of Jiangsu Province (the First Affiliated Hospital of Nanjing Medial University), Nanjing 210029, China.
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