AI Article Synopsis
- Curcumin liposomes (CUR-LPs) were analyzed for their properties, revealing particle diameter of 167 nm and a zeta potential of -34 mV, which indicates good stability.
- These liposomes exhibit pseudo-pH sensitivity, allowing them to remain stable in gastric fluid while gradually releasing curcumin in intestinal fluid, with 21.82% and 27.32% consumption in SGF and SIF, respectively.
- CUR-LPs show promise in alleviating symptoms of ulcerative colitis, including weight loss and intestinal damage, while also reducing markers of inflammation in an animal model.
Article Abstract
Curcumin liposomes (CUR-LPs) was identified by evaluating morphology, appearance, zeta potential, particle diameter, and drug encapsulation efficiency. The results indicated that particle diameter, surface charge and polydispersity index (PDI) of curcumin (CUR)-loaded anionic liposomes were 167 nm, -34 mV and 0.09, respectively. CUR-LPs is high stable pseudo-pH-sensitive nanoparticles system which has a favorable stability in simulated gastric fluid and slower degradation rate allowing CUR sustained release for prolonged times in simulated intestinal fluid. Within 1 h, the CUR consumption was 21.82% in simulated gastric fluid (SGF) and 27.32% in simulated intestinal fluid (SIF), respectively. CUR-LPs could attenuate clinical symptoms including weight loss, diarrhea and fecal bleeding. Especially, it could also prevent dextran sulfate sodium salt (DSS)-inducedcolon tissue damage and colon shortening, and reduce the production of malondialdehyde (MDA), colonic myeloperoxidase (MPO), Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in animal model. Our study illustrated that liposomes (LPs) was a potential carrier to develop the colon-specific drug delivery system incorporating CUR for treating ulcerative colitis.
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| http://dx.doi.org/10.1016/j.fct.2021.112123 | DOI Listing |
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