Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/DAD.0000000000001791 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Cell Biology and Pathology, New York, NY, USA.
Background: Possession of the APOE4 allele is the strongest genetic risk factor for developing the sporadic form of Alzheimer's disease (AD). Studies investigating APOE4's associated AD risk have largely centered on APOE4's propensity to regulate the deposition of extracellular amyloid beta plaques. More recent attempts to characterize APOE4's role in AD have brought into question the role APOE4 may possess in modulating the pathogenesis of intracellular tau tangles.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Biofluidic biomarkers concord with postmortem molecular studies, suggesting that the endosomal recycling pathway regulated by SORL1's interaction with the retromer protein VPS2b is commonly disrupted in late-onset, 'sporadic', Alzheimer's disease (AD). Here, a program for developing a neuroimaging-based biomarker will be reviewed. The program is anchored by findings in support of the conclusion that, because of its distinct network properties, the trans-entorhinal cortex is heavily dependent on the recycling pathway.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea, Republic of (South).
Background: Large-scale genome-wide association studies (GWAS) of Alzheimer's disease (AD) from European ancestry identified many genetic variants associated with clinical diagnosis of AD dementia. However, it remains unclear whether these AD-related variants are associated with AD biomarkers, particularly hippocampal atrophy, a well-known neurodegeneration biomarker of AD in a Korean population. In this study, we investigated the association between known AD risk single nucleotide polymorphisms (SNPs) and hippocampal atrophy along the AD continuum in older Korean adults.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Background: Limbic predominant age-related TDP-43 encephalopathy (LATE) is a common co-pathology in Alzheimer's disease (AD) and is associated with advanced cognitive impairment and severe atrophy in limbic regions. In AD, various maturation stages for tau neurofibrillary tangles have been characterized and can be selectively marked by monoclonal tau antibodies, providing insight into disease progression. Indeed, AD tau pathology progresses from an early "paperclip" conformation, marked by the MC1 epitope to a C-terminally truncated form of tau, marked by MN423 epitope.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Cognitive Neuroscience Center, University of San Andrés, Victoria, Buenos Aires, Argentina.
Background: Automated speech and language analysis (ASLA) represents a powerful innovation for detecting and monitoring persons with or at risk for dementia. Given its cost-efficiency and automaticity, its impact can be vital for under-resourced communities, such Spanish-speaking Latinos. However, ASLA markers are understudied in this group and may differ from those established in widely studied populations (e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!