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Lessons about physiological relevance learned from large-scale meta-analysis of co-expression networks in brain organoids.
PLoS Biol
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Maisonneuve-Rosemont Hospital Research Centre (CRHMR), Department of Medicine, University of Montreal, Montreal, Quebec, Canada.
Integrative analysis of publicly available scRNA-seq data facilitates deeper understanding of biological phenomena with strong statistical power and high resolution. A new study in this issue of PLOS Biology examined the fidelity of various brain organoid protocols in reference to human primary developing brain by gene co-expression relationships with million-scale collection of public scRNA-seq data sets.
View Article and Find Full Text PDFProtein -palmitoylation regulates the virulence of plant pathogenic fungi.
mBio
December 2024
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Protein -palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions. However, its roles in the virulence of plant pathogenic fungi remain underexplored. In a recent study, Y.
View Article and Find Full Text PDFRegulatory networks may evolve to favor adaptive foresight.
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December 2024
Centro de Biotecnología y Genómica de Plantas (CBGP), Universidad Politécnica de Madrid (UPM), Madrid, Spain.
Pleiotropy-a single mutation altering many traits-has long been seen as hindering adaptation. A new study in PLOS Biology offers a striking counterexample, suggesting that regulatory networks may evolve to ensure mutations are simultaneously beneficial in correlated environments.
View Article and Find Full Text PDFGlycerolipids disrupt regulatory T-cells in asthma.
Eur Respir J
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Division of Immunology, Boston Children's Hospital, Boston, MA, USA
Synthetic gene circuits drive disease-fighting T cells.
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Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease.
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