Control promotion and prevention of platelet adhesion are important for various biomedical applications. In the past, surface topography and chemical modifications have been commonly utilized for tailoring the promotion and prevention of platelet adhesion. Recently, lotus-leaf-inspired superhydrophobicity has appeared as an efficient avenue to prevent platelet adhesion. However, such extreme water repellent interfaces fail to perform upon prolonged and continuous exposure to aqueous phase. In this communication, the strategic use of a catalyst-free 1,4-conjugate addition reaction between amine and acrylate allowed us to investigate the impact of two distinct underwater oil-wettability on platelet adhesion activity. While underwater superoleophobicity inhibited platelet-adhesion, a highly aggregated fibrous network of adhered platelets was observed on underwater superoleophilic coating. Further, this biocompatible and haemocompatible underwater superoleophobic multilayer coating was deposited on a commercially available catheter tube to examine its potential towards the prevention of platelet attachment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/asia.202100143 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-crosslinking nanoclay/oxidized cellulose hydrogel bandage with robust mechanical strength, antibacterial and adhesive properties for emergency hemostasis.
J Colloid Interface Sci
December 2024
College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China. Electronic address:
Emergency bleeding presents significant challenges such as high blood flow and rapid hemorrhaging. However, many existing hemostatic bandages face limitations, including the uncontrolled release of hemostatic agents, insufficient mechanical strength, poor adhesion, and complex manufacturing processes. To address these limitations, we developed a multifunctional hydrogel bandage for emergency hemostasis using a one-pot synthesis method.
View Article and Find Full Text PDFUnraveling the mystery: effect of trapped air on platelet adhesion on hydrophobic nanostructured titanium dioxide.
Biomater Sci
January 2025
Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, College of Physical Science and Technology, Xiamen University, Xiamen 361005, China.
Nature-inspired superhydrophobic materials have attracted considerable interest in blood-contacting biomedical applications due to their remarkable water-repellent and self-cleaning properties. However, the interaction mechanism between blood components and superhydrophobic surfaces remains unclear. To explore the effect of trapped air on platelet adhesion, we designed four distinct hydrophobic titanium dioxide (TiO) nanostructures with different fractions of trapped air.
View Article and Find Full Text PDFConstruction of Loop Polyzwitterion Brushes on PET Sheets via the Chain-End Closure Strategy To Improve Antifouling and Hemocompatible Properties.
Langmuir
January 2025
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
Steric stabilization and lubrication give loop polymer brushes enhanced antifouling properties. In the study, linear zwitterionic poly(NMASMCMS) brushes were first constructed on a poly(ethylene terephthalate) (PET) surface through surface-initiated reversible addition-fragmentation chain-transfer (SI-RAFT) polymerization. The tethered linear brushes on sheets were then thiolated with ethanolamine, followed by oxidation to form loop brushes.
View Article and Find Full Text PDFSystem vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans.
Nat Immunol
January 2025
Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.
We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity.
View Article and Find Full Text PDFComparison of glued platelet-rich fibrin membrane and noneugenol pack as periodontal dressings after gingival depigmentation.
J Indian Soc Periodontol
December 2024
Department of Periodontology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
Article Synopsis
- Periodontal surgery often requires dressings for protection and healing, with common options like noneugenol packs having drawbacks such as plaque buildup and minimal healing benefits.
- Platelet-rich fibrin (PRF) membranes promote faster healing due to their growth factors but typically require sutures for stability.
- This case report explores the use of PRF membranes combined with N-butyl cyanoacrylate adhesive as a promising alternative to traditional dressings, potentially eliminating the need for suturing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!