Fertility drugs have not definitively been linked to malignant melanoma. By the use of data from a large nationwide cohort of women aged 20.0-45.0 years and living in Denmark between January 1, 1995 and December 31, 2011, we assessed the association between the use of fertility drugs and the risk of malignant melanoma. Information on fertility status and the use of fertility drugs was obtained from the population-based Danish Infertility Cohort. Cox proportional hazard regression models were applied to estimate hazard ratios and 95% confidence intervals with adjustment for potential confounders. The study population comprised 1,330,954 women, of whom 86,231 (6.5%) were treated with fertility drugs. During a median follow-up of 21.0 years, 6,139 women were diagnosed with malignant melanoma. Compared with fertile women, women with fertility challenges who had used any fertility drugs had an increased risk of malignant melanoma (hazard ratio = 1.14; 95% confidence interval = 1.02-1.27). Furthermore, the use of specific types of fertility drugs (clomiphene, gonadotropins, human chorionic gonadotropin, gonadotropin-releasing hormone preparations, and progesterone) was also associated with an increased risk of malignant melanoma, with hazard ratios ranging between 1.09 and 1.13; however, the association did not reach statistical significance. Our findings indicate that the use of fertility drugs was associated with a modestly increased risk of malignant melanoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jid.2021.02.752 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic and Additive Inhibition of UDP-Glucuronosyltransferase 1A9 by Endogenous and Foodborne Inhibitors.
Basic Clin Pharmacol Toxicol
January 2025
Collaborative Innovation Center of Targeted Development of Medicinal Resources (iCTM) & Research Center of Aquatic Organism Conservation and Water Ecosystem Restoration, Anqing Normal University, Anqing, China.
UDP-glucuronosyltransferases (UGTs) are responsible for inactivation of a variety of drugs, endogenous hormones and environmental toxicants. Chemical inhibitors are a common factor decreasing UGT activities and furtherly inducing health problems. Although simultaneously encountering different inhibitors is readily to occur, no information is available for combined inhibition of UGT.
View Article and Find Full Text PDFCo-Treatment with Cranberry and Vitamin-C Mitigates Reproductive Toxicities Induced by Phenobarbital in Male Rats.
Cell Physiol Biochem
December 2024
Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Background/aims: Phenobarbital (PB), commonly used for epilepsy management, is associated with testicular dysfunction after prolonged use. This study aimed to evaluate the ameliorative effects of cranberry (CB) and vitamin C (Vit-C) on PB-induced reproductive toxicity in rats.
Methods: Forty male Wistar rats were divided into five groups.
Do Exercise and Magnesium Sulfate Improve Infertility Caused by Lithium Carbonate in Male Rats?
Adv Biomed Res
November 2024
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Background: Lithium (Li) is widely used in the treatment of bipolar disorder, but it may lead to toxicity in the reproductive system. Considering the harmful effect of Li consumption on fertility and the positive effect of magnesium sulfate (MgSo) and moderate-intensity training (MIT) on improving the quality of men's sperm, the current research was conducted to determine the impact of MIT and MgSo on infertility caused by Li.
Materials And Methods: Seventy-two male rats were divided into 12 groups, control, Li10 mg/kg/day/ip, MgSo 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo; Li10+MIT; Li10+MgSo+MIT; Li40+MgSo; Li40+MIT; Li40+MgSo+MIT.
Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role.
Sci Rep
December 2024
Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Diabetes can affect male fertility via oxidative stress and endocrine system disruption. Nanomedicine based on natural products is employed to address diabetes complications. The current study aims to investigate the potential beneficial effect of propolis extract nanoparticles against diabetes-induced testicular damage in male rats.
View Article and Find Full Text PDFMaternal Morbidity and Medically Assisted Reproduction Treatment Types.
Obstet Gynecol
December 2024
Centre for Longitudinal Studies, Social Research Institute, University College London, London, United Kingdom; Population Science, Huntsman Cancer Institute, the Department of Family and Consumer Studies, the Department of Obstetrics and Gynecology, and the Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City; Max Planck Institute for Demographic Research, Rostock, Germany; the Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland; and the Max Planck - University of Helsinki Center for Social Inequalities in Population Health, Rostock, Germany and Helsinki, Finland.
Article Synopsis
- The study aims to analyze the risk of maternal morbidity based on how pregnancies were achieved, focusing on various methods of medically assisted reproduction like fertility drugs, IUI, and ART.
- Data from Utah's birth certificates (2009-2017) showed that 4.8% of pregnancies were from assisted reproduction, with maternal morbidity defined by complications like blood transfusions and ICU admissions.
- Results indicated higher maternal morbidity risks for those using assisted reproduction, particularly with ART and autologous oocytes, although these risks decreased when controlling for factors like multiple pregnancies and existing health issues.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!