AI Article Synopsis
- Hepatocellular carcinoma (HCC) is prevalent in adolescents and young adults (AYAs) in hepatitis B-endemic regions, and this study compares AYAs (ages 13-39) to older adults (OAs, ages 40+) who underwent liver resection for HCC.
- Among 1952 patients studied, AYAs demonstrated fewer instances of cirrhosis but had more advanced tumor characteristics; their postoperative outcomes were similar to OAs, yet AYAs exhibited comparable overall survival but a shorter time to recurrence.
- The findings indicate that AYAs experience a higher recurrence rate post-surgery for HCC, suggesting the need for closer monitoring after liver resection in younger
Article Abstract
Background: Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) in areas with endemic hepatitis B virus infection. We sought to characterize clinical features and long-term outcomes among AYAs versus older adults (OAs) who underwent HCC resection.
Methods: From a Chinese multicenter database, patients were categorized as AYA (aged 13-39 years) versus OA (aged ≥40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were compared. Multivariable Cox-regression analyses were performed to identify the impact of age on OS and TTR.
Results: Among 1952 patients, 354(22.2%) were AYAs. AYAs were less likely to have cirrhosis yet were likely to have advanced tumor pathological characteristics than OAs. Postoperative morbidity and mortality were comparable. Compared with OAs, AYAs had a comparable OS but a decreased TTR. Multivariable analyses identified that young age (<40 years) was independently associated with poorer TTR.
Conclusions: Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among AYAs.
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| http://dx.doi.org/10.1016/j.amjsurg.2021.03.009 | DOI Listing |
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