See(quence) and ye shall find: higher-order genome folding in intact single cells.

Mol Cell

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; New York Stem Cell Foundation - Robertson Investigator. Electronic address:

Published: March 2021

Payne et al. (2020) combine in situ imaging and ex situ sequencing via spatially resolved unique molecular barcodes to query higher-order genome folding patterns in intact single nuclei from mouse embryos and human fibroblasts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295612PMC
http://dx.doi.org/10.1016/j.molcel.2021.02.035DOI Listing

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