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Potential population-level effects of HIV self-test distribution among key populations in Côte d'Ivoire, Mali, and Senegal: a mathematical modelling analysis.
Lancet HIV
August 2024
Medical Research Council Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK.
Article Synopsis
- The ATLAS program distributed approximately 380,000 HIV self-testing kits to high-risk populations in Côte d'Ivoire, Mali, and Senegal between 2019-2021 to improve HIV diagnosis and treatment coverage.
- A deterministic compartmental model was used to estimate the impacts of the ATLAS program and future scale-up of HIV self-testing on HIV diagnoses, treatment initiation, incidence, and related mortality among key populations.
- The model predicted that ATLAS could result in around 1,500 additional HIV diagnoses across the three countries during 2019-2021, significantly contributing to increased awareness and potential treatment for HIV.
HIV-1 Gag, Pol, and Env diversified with limited adaptation since the 1980s.
mBio
March 2024
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Unlabelled: Knowledge of HIV-1 global sequence diversity is critical for developing an effective prophylactic against HIV-1 infection. We developed the Hervé platform to analyze and visualize trends in HIV-1 diversification. Using Hervé, we analyzed 4,830 Env, 4,407 Gag, and 3,002 Pol publicly available independent sequences corresponding to subtypes A1, A6, B, C, D, F1, and G and circulating recombinant forms (CRFs) 01_AE, 02_AG, and 07_BC; sequences were sampled between 1980 and 2020 from 82 countries.
View Article and Find Full Text PDFHealth economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: a systematic review.
Wellcome Open Res
January 2023
Big Data Institute, University of Oxford, Oxford, UK.
In lower tuberculosis (TB) incidence countries (<100 cases/100,000/year), screening and preventive treatment (PT) for latent TB infection (LTBI) among people living with HIV (PLWH) is often recommended, yet guidelines advising which groups to prioritise for screening can be contradictory and implementation patchy. Evidence of LTBI screening cost-effectiveness may improve uptake and health outcomes at reasonable cost. Our systematic review assessed cost-effectiveness estimates of LTBI screening/PT strategies among PLWH in lower TB incidence countries to identify model-driving inputs and methodological differences.
View Article and Find Full Text PDFSexual and gender minority publication trends in the dermatology literature.
Arch Dermatol Res
November 2022
Division of Dermatology, The Ohio State University Wexner Medical Center, 540 Officenter Place, Suite 240, Columbus, OH, 43230, USA.
In the greater medical literature, publication rates on topics relevant to the lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) communities have been on the rise. The publication rates in the dermatology literature have not yet been described. We performed an analysis of the dermatology literature from 1980-2020 to characterize LGBTQ-relevant publication rates and themes over time.
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