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Rethinking Arterial Spin Labeling Perfusion in Neurodegeneration Considering Global and Regional Changes.
Cureus
November 2024
Diagnostic Imaging, St. Marina University Hospital, Varna, BGR.
Recent advancements in arterial spin labeling (ASL) MRI have significantly improved our understanding of cerebral perfusion in neurodegenerative diseases. Traditionally, the focus has been on regional perfusion deficits corresponding to specific neural pathologies. However, this localized approach may overlook the influence of global cerebral blood flow alterations.
View Article and Find Full Text PDFAssessment of cerebral perfusion alterations in dementia with Lewy bodies and Alzheimer's disease.
Quant Imaging Med Surg
December 2024
Department of Radiology, Tianjin First Central Hospital, Tianjin, China.
Background: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are common forms of dementia, characterized by overlapping clinical symptoms. Functional neuroimaging can provide valuable information for precise diagnosis. Our objective was to explore cerebral perfusion alterations in DLB and AD, and to determine which perfusion parameters are helpful in distinguishing DLB and AD.
View Article and Find Full Text PDFComparison of normalized cerebral blood flow between different post-processing methods of dynamic susceptibility contrast perfusion-weighted imaging and arterial spin labeling in gliomas with different grading.
Quant Imaging Med Surg
December 2024
Department of Radiology, the 8th Medical Center of PLA General Hospital, Beijing, China.
Background: Two post-processing methods of dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI), arterial input function (AIF) and gamma-variate fitting (GVF), can both derive cerebral blood flow (CBF). Moreover, AIF can provide T2* and T1 leakage indicators. This study aimed to compare the consistency of normalized CBF between different post-processing methods of DSC-PWI and arterial spin labeling (ASL) in gliomas, and take the quantitative metrics percentage of signal recovery (PSR) as a reference to verify the value of T2* and T1 leakage indicators in characterizing leakage effect and evaluating the grading of gliomas.
View Article and Find Full Text PDF18F-FDG metabolic abnormalities precede perfusion and atrophic changes in diagnosis of early frontotemporal dementia: study from a tertiary care university hospital.
Nucl Med Commun
December 2024
Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, India.
Objective: Diagnosis of early onset dementia is critical for initiating management. Although structural MRI is an established procedure for dementia evaluation, early cases may be missed. Neurodegenerative diseases lead to reductions in glucose consumption and grey matter volume loss.
View Article and Find Full Text PDFImpact of perioperative cerebral blood flow evaluation using arterial spin labeling in a patient undergoing carotid artery stenting.
J Clin Neurosci
December 2024
Department of Neurosurgery, Gifu Medical University, 1-1 Yanagido, Gifu City, Gifu, Japan.
Background: Hyperperfusion syndrome (HPS) is one of the most serious complications after carotid artery stenting (CAS). Arterial spin labeling (ASL) is a noninvasive method for assessing cerebral perfusion. This study aimed to evaluate the utility of ASL compared to that of SPECT in evaluating changes in intracranial blood flow during the perioperative period of CAS.
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