AI Article Synopsis
- The study investigates how different grades and sources of Poly (ethylene oxide) (PEO) affect the compaction characteristics of abuse-deterrent formulations (ADFs) used in tablet manufacturing.
- It utilizes a Styl'One compaction simulator to analyze factors like particle size, thermal behavior, tabletability, compressibility, and elastic recovery under varying conditions.
- The findings indicate that high molecular weight PEOs improve tablet strength, while the source of PEO influences compaction properties, but this effect lessens when combined with model drugs.
Article Abstract
Poly (ethylene oxide) (PEO) has been widely used in abuse-deterrent formulations (ADFs) to increase tablet hardness. Previous studies have shown that formulation variables such as processing conditions and particle size of PEO can affect ADF performance in drug extraction efficiency. This work aims to understand the effect of PEO grades and sources on the compaction characteristics of model ADFs. PEOs from Dow Chemical and Sumitomo Chemical with different molecular weights were examined using a Styl'One compaction simulator at slow, medium, and fast tableting speeds. Particle-size distribution, thermal behavior, tabletability, compressibility using the Heckel model, compactibility, and elastic recovery were determined and compared between the neat PEOs and model ADFs. Multivariate linear regression was performed to understand the effect of compression conditions and PEO grades and sources. Our results show that neat PEOs with high molecular weight exhibit high tabletability. The source of neat PEOs contributes to the difference in tabletability, out-die compressibility, compactibility, and elastic recovery. However, the influence of the PEO source on tabletability and compactibility decreases after adding the model drug. In our model ADFs, tablets using PEOs with high molecular weight have high crushing strength, and tablets using PEOs from Dow Chemical display low elastic recovery.
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| http://dx.doi.org/10.1016/j.xphs.2021.03.008 | DOI Listing |
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