The increasing prevalence of periodontal and cardiovascular diseases is the result of a sedentary lifestyle associated with poor diet, obesity, hypercholesterolaemia, smoking habits, alcohol consumption and stress. The present study aims to uncover molecular associations between periodontitis and coronary heart disease using an unbiased strategy of automatic text mining traditionally applied to bibliometric studies. A total of 1590 articles on these diseases were retrieved from the Web of knowledge database and searched using the VOS viewer to create a network of keywords associated with both diseases. These data were supplemented with data from DisGeNET, which stores known associations to either periodontitis or coronary heart disease. Overall, the automated text mining approach presented here highlighted inflammatory molecules as common associations between periodontitis and coronary heart disease. Specifically, this study showed that molecules such as C-reactive protein, interleukins 6 and 1-β, myeloperoxidase, and matrix metalloproteinase 9 are simultaneously associated with periodontitis and coronary artery disease by both text mining and DisGeNET analyses. This association validates the multiplex assessment of salivary inflammatory markers as a tool to assess cardiovascular disease risk and could become an important tool to identify common molecular targets to monitor both diseases simultaneously. In addition, the text mining protocol and subsequent data processing and methods using bioinformatics tools could be useful to uncover links between other diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/1354750X.2021.1904002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of Systemic Health Indicators, Including C-Reactive Protein and eGFR, in Predicting Periodontal Disease: A Longitudinal Study.
Int J Mol Sci
January 2025
Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary.
C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) are key biomarkers reflecting systemic inflammation and metabolic dysfunction. This study explored systemic and oral health indicators, including CRP and eGFR, as potential factors associated with periodontitis, using a longitudinal clinical dataset comprising 23,742 records from patients identified by ICD-10 codes between 2015 and 2022. Univariate Cox analysis and Gompertz models, selected based on AIC and BIC after evaluating alternative models, were employed to assess the predictive roles of CRP and eGFR in periodontitis incidence, adjusting for oral and systemic health factors.
View Article and Find Full Text PDFAnthropometric and Sociodemographic Correlates of Dental Caries and Gingival Health in Children With Special Healthcare Needs at a Saudi Tertiary Care Hospital.
Spec Care Dentist
January 2025
Department of Prosthetic Dental Sciences, College of Dentistry, Qassim University, Qassim, Saudi Arabia.
Aims: To evaluate the impact of anthropometric and sociodemographic factors on dental caries and gingival health among children with special healthcare needs (SHCN).
Methods And Results: This cross-sectional study involved 108 children, aged 4-14 years, with congenital heart disease, childhood cancer, bleeding disorders, various syndromes, and multiple conditions. Caregivers completed a sociodemographic questionnaire, and children underwent dental examinations to assess caries, gingival health, and oral hygiene.
Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions.
World J Psychiatry
January 2025
Mental Health Education and Counseling Center, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China.
This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing (MI) in addressing anxiety and depression among young and middle-aged patients following percutaneous coronary intervention. It further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease management. MI aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhancing intrinsic motivation.
View Article and Find Full Text PDFCorrelation of lipid profile APO A1 and APO B100 in chronic periodontitis patients leading to coronary artery disease.
Natl J Maxillofac Surg
November 2024
C.B.M.R., Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Background: Increased attention has been focused on the association of periodontal disease with cardio-metabolic syndrome. Although the associations are multi-factorial, very few studies have explored the role of lipoprotein Apo A1 and Apo B100 with chronic periodontitis. Additionally, obstructive sleep apnea (OSA), a chronic multi-factorial respiratory disease, consists of a temporary decrease or cessation of breath for ≥ 10 seconds and leads to a reduction in blood oxygen saturation of more than 3% to 4% and/or neurological arousal.
View Article and Find Full Text PDFUnlabelled: Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. Toll-like receptors (TLRs) are present on gingival epithelial cells and recognize pathogen-associated molecular patterns (PAMPs) on pathogenic bacteria, induce the secretion of proinflammatory cytokines, and initiate innate and adaptive antigen-specific immune responses to eradicate the invading microbes. Since PD is a chronic inflammatory disease, TLR2/TLR4 plays a vital role in disease pathogenesis and maintaining the periodontium during health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!