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Statins for vascular dementia: A hype or hope.
Neuroscience
December 2024
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, AlBeheira, Egypt.
Article Synopsis
- Vascular dementia (VaD) is the second most common type of dementia after Alzheimer’s disease, characterized by cognitive impairment and memory loss, often linked to cerebral amyloid angiopathy (CAA).
- Early diagnosis and the use of anti-inflammatory treatments can potentially prevent the development of VaD, but there are currently no effective drugs available specifically for its management.
- Statins, commonly used for lowering cholesterol, may show promise in treating VaD and improving cognitive function, but the exact mechanisms of their effectiveness are still not well understood.
A review on the treatment of hyperlipidemia with Erchen Decoction.
Front Pharmacol
November 2024
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Hyperlipidemia, commonly referred to as dyslipidemia, is characterized by elevated serum cholesterol and/or triglyceride levels. This condition contributes significantly to the high mortality rates associated with cardiovascular diseases, posing a serious threat to global health. Although statins remain the predominant pharmacological treatment for hyperlipidemia, their associated side effects have led to a growing interest in alternative therapeutic approaches.
View Article and Find Full Text PDFNew insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer's disease.
Front Neurosci
September 2024
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Alzheimer's disease (AD) is increasingly recognized as being intertwined with the dysregulation of lipid metabolism. Lipids are a significant class of nutrients vital to all organisms, playing crucial roles in cellular structure, energy storage, and signaling. Alterations in the levels of various lipids in AD brains and dysregulation of lipid pathways and transportation have been implicated in AD pathogenesis.
View Article and Find Full Text PDFNew Insights Into the Treatment of Hyperlipidemia: Pharmacological Updates and Emerging Treatments.
Cureus
June 2024
Interventional Cardiology, St. Joseph's Medical Center, Stockton, USA.
Cardiovascular diseases are the leading causes of global mortality and morbidity. Hyperlipidemia is a significant risk factor for atherosclerosis and subsequent cardiovascular diseases. Hyperlipidemia is characterized by imbalances in blood cholesterol levels, particularly elevated low-density lipoprotein cholesterol and triglycerides, and is influenced by genetic and environmental factors.
View Article and Find Full Text PDFCost effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis.
EClinicalMedicine
July 2024
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Background: Cardiovascular disease (CVD) continues to impart a large burden on the global population, especially in lower income countries where affordability limits the use of cardiovascular medicines. A fixed dose combination strategy of at least 2 blood pressure lowering medications and a statin with aspirin in a single pill has been shown to reduce the risk of incident CVD by 38% in primary prevention in a recent meta-analysis. We report the in-trial (median follow-up: 5 years) cost-effectiveness of a fixed dose combination (FDC) pill in different income groups based on data from that meta-analysis.
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