Globally, the COVID-19 pandemic has become a threat to humans and to the socioeconomic systems they have developed since the industrial revolution. Hence, governments and stakeholders call for strategies to help restore normalcy while dealing with this pandemic effectively. Since till now, the disease is yet to have a cure; therefore, only risk-based decision making can help governments achieve a sustainable solution in the long term. To help the decisionmakers explore viable actions, we propose a risk-based assessment framework for analyzing COVID-19 risk to areas, using integrated hazard and vulnerability components associated with this pandemic for effective risk mitigation. The study is carried on a region administrated by Jaipur municipal corporation (JMC), India. Based on the current understanding of this disease, we hypothesized different COVID-19 risk indices (C19Ri) of the wards of JMC such as proximity to hotspots, total population, population density, availability of clean water, and associated land use/land cover, are related with COVID-19 contagion and calculated them in a GIS-based multicriteria risk reduction method. The results showed disparateness in COVID-19 risk areas with a higher risk in north-eastern and south-eastern zone wards within the boundary of JMC. We proposed prioritizing wards under higher risk zones for intelligent decision making regarding COVID-19 risk reduction through appropriate management of resources-related policy consequences. This study aims to serve as a baseline study to be replicated in other parts of the country or world to eradicate the threat of COVID-19 effectively.
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http://dx.doi.org/10.1111/risa.13724 | DOI Listing |
CJEM
January 2025
Department of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Objectives: Postponing scheduled surgeries may alleviate emergency department (ED) crowding by increasing inpatient beds for ED patients but the impact of such measures are unclear. We determined if scheduled surgery cancellations for inguinal hernia and gallbladder disease during the coronavirus pandemic affected ED presentations, hospitalizations, and complications.
Methods: This database review included Albertans ≥ 18 with ED presentations for inguinal hernia and gallbladder disease from March 1, 2018 to May 31, 2022.
Background: The global outbreak of COVID-19, caused by the SARS-CoV-2 virus, has been linked to long-term neurological complications, including Alzheimer's disease (AD) among seniors. However, the precise genetic impact of COVID-19 on long-term AD development remains unclear.
Method: This study leveraged genome-wide association study (GWAS) data and genotype data to explore the genetic correlation between AD and various COVID-19 phenotypes across European ancestry (EA) and African ancestry (AA).
Alzheimers Dement
December 2024
University of South Alabama, Mobile, AL, USA.
Background: Many survivors of lung injury, including those with bacterial pneumonia and COVID-19, suffer from incident dementia. Patients who have had pneumonia and other infections are at a higher risk for developing Alzheimer's disease and related dementias (ADRD) (Chu et al., BBI, 2022, Sipila et al.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA.
Background: AD/ADRD diseases currently impact more than 6 million people in the US. Rare forms of AD/ADRD are caused directly and unambiguously by genetic mutations. However, most AD/ADRD burden is complex in etiology and thought to result from an interplay among multiple incompletely understood genetic, biochemical, lifestyle, environmental and psychosocial risk factors.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, USA.
Background: SARS-CoV-2 causes a variety of neurological sequelae in COVID-19 survivors, including fatigue and cognitive dysfunction. Endothelial dysfunction is the unifying and central mechanism of COVID-19 illness and a major risk factor for vascular dementia (VaD). Endothelial dysfunction stems, in part, from an imbalance between nitric oxide (NO) generated by the endothelial nitric oxide synthase (eNOS) and reactive oxidant species produced by uncoupled-eNOS.
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