Deep neural networks have been successfully applied in learning the board games Go, chess, and shogi without prior knowledge by making use of reinforcement learning. Although starting from zero knowledge has been shown to yield impressive results, it is associated with high computationally costs especially for complex games. With this paper, we present which is a neural network based engine solely trained in supervised manner for the chess variant crazyhouse. Crazyhouse is a game with a higher branching factor than chess and there is only limited data of lower quality available compared to . Therefore, we focus on improving efficiency in multiple aspects while relying on low computational resources. These improvements include modifications in the neural network design and training configuration, the introduction of a data normalization step and a more sample efficient Monte-Carlo tree search which has a lower chance to blunder. After training on 569537 human games for 1.5 days we achieve a move prediction accuracy of 60.4%. During development, versions of played professional human players. Most notably, achieved a four to one win over 2017 crazyhouse world champion Justin Tan (aka ) who is more than 400 Elo higher rated compared to the average player in our training set. Furthermore, we test the playing strength of on CPU against all participants of the second Crazyhouse Computer Championships 2017, winning against twelve of the thirteen participants. Finally, for we continue training our model on generated engine games. In 10 long-time control matches playing wins three games and draws one out of 10 matches.
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http://dx.doi.org/10.3389/frai.2020.00024 | DOI Listing |
Science
October 2024
Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Science
May 2024
Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA.
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 open chromatin regions, including thousands of sequences with cell type-specific accessibility and variants associated with brain gene regulation. In primary cells, we identified 46,802 active enhancer sequences and 164 variants that alter enhancer activity.
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May 2024
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Science
May 2024
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics datasets into a resource comprising >2.
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May 2024
Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD, 21205, USA.
When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers.
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