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| http://dx.doi.org/10.1016/j.pld.2020.12.001 | DOI Listing |
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Regulation of calcium homeostasis in endoplasmic reticulum-mitochondria crosstalk: implications for skeletal muscle atrophy.
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This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. Calcium is vital for both regulating muscle excitation-contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium from the endoplasmic reticulum (ER) is mediated by receptors such as the ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R), which is crucial for skeletal muscle contraction.
View Article and Find Full Text PDFHypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis.
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View Article and Find Full Text PDFEvaluating the impact of faculty development programs at the workplace by using reflective critique writing technique.
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Dean RARE/ORIC, Islamic International Medical College, RIPHAH university, Rawalpindi, Pakistan.
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View Article and Find Full Text PDFGenome-wide identification of CAMTA gene family in teak (Tectona grandis) and functional characterization of TgCAMTA1 and TgCAMTA3 in cold tolerance.
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Research Institute of Tropical Forestry, Chinese Academy of Forestry, Guangzhou, 520521, China.
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Insights into phosphatidic acid phosphatase and its potential role as a therapeutic target.
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Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ, 08901, USA.
Phosphatidic acid phosphatase, a conserved eukaryotic enzyme that catalyzes the Mg-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol, has emerged as a vital regulator of lipid homeostasis. By controlling the balance of phosphatidic acid and diacylglycerol, the enzyme governs the use of the lipids for synthesis of the storage lipid triacylglycerol and the membrane phospholipids needed for cell growth. The mutational, biochemical, and cellular analyses of yeast phosphatidic acid phosphatase have provided insights into the structural determinants of enzyme function with the understanding of its regulation by phosphorylation and dephosphorylation.
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