The development of new strategies for the preparation of chiral amines is an important objective in organic synthesis. In this , we summarize our approach for catalytically accessing nucleophilic aminoalkyl metal species from 2-azadienes, and its application in generating a number of important but elusive chiral amine scaffolds. Reductive couplings with ketones and imines afford 1,2-amino tertiary alcohols and 1,2-diamines, respectively, whereas fluoroarylations of -difluoro-2-azadienes deliver α-trifluoromethylated benzylic amines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963344 | PMC |
| http://dx.doi.org/10.1055/s-0037-1611770 | DOI Listing |
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