AI Article Synopsis
- Chronic inflammatory arthritis in children, known as juvenile idiopathic arthritis (JIA), shows diverse presentations but shares similarities with adult-onset arthritis, except for some unique pediatric forms.
- Traditional approaches have treated JIA and adult arthritis as separate entities, leading to a lack of overlap in classification terms between the two groups.
- Recent research highlights the need for a revised approach that integrates biological categories and genetic data to better understand and categorize inflammatory arthritis in both children and adults.
Article Abstract
Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be restricted to children. Nevertheless, paediatric and adult rheumatologists have historically addressed disease classification separately, yielding a juvenile idiopathic arthritis (JIA) nomenclature that exhibits no terminological overlap with adult-onset arthritis. Accumulating clinical, genetic and mechanistic data reveal the critical limitations of this strategy, necessitating a new approach to defining biological categories within JIA. In this Review, we provide an overview of the current evidence for biological subgroups of arthritis in children, delineate forms that seem contiguous with adult-onset arthritis, and consider integrative genetic and bioinformatic strategies to identify discrete entities within inflammatory arthritis across all ages.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355214 | PMC |
| http://dx.doi.org/10.1038/s41584-021-00590-6 | DOI Listing |
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