AI Article Synopsis
- Long noncoding RNAs (lncRNAs) are key regulators involved in various health issues, but their role in intrahepatic cholestasis of pregnancy (ICP) remains under-researched.
- A microarray analysis identified significant changes in lncRNA and mRNA expression in ICP patients, revealing notable pathways related to lipid metabolism, apoptosis, and oxidative stress.
- The study highlighted three specific lncRNAs with potential diagnostic and prognostic significance for ICP, marking a first in understanding their role in this condition.
Article Abstract
Long noncoding RNAs (lncRNAs) are a class of important regulators participating in various pathological processes. Until now, the role of lncRNAs in the occurrence and development of intrahepatic cholestasis of pregnancy (ICP) has rarely been investigated. The data from microarray screening revealed 58 upregulated and 85 downregulated lncRNAs and 47 upregulated and 71 downregulated mRNAs in ICP patients compared to healthy controls. Bioinformatics analysis revealed biological processes focused on lipid metabolism, apoptosis, cell cycle, cell differentiation, and oxidative stress. Furthermore, the expressions of three lncRNAs (ENST00000505175.1, ASO3480, and ENST00000449605.1) chosen for verification were significantly decreased and showed the diagnostic and prognostic value for ICP based on ROC analysis. This is the first study to report the specific role of lncRNAs in ICP, which may be helpful for the diagnosis and prognosis of ICP clinically.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936904 | PMC |
| http://dx.doi.org/10.1155/2021/8858326 | DOI Listing |
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