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| http://dx.doi.org/10.1002/jmd2.12194 | DOI Listing |
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[F]SMBT‐1 PET can visualize the spatial distribution of reactive astrogliosis in patients with neurodegenerative dementias.
Alzheimers Dement
December 2024
CYRIC, Tohoku University, Sendai, Japan
Background: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO‐B) are used to visualize reactive astrogliosis in the living brain. [F]SMBT‐1, a MAO‐B selective PET tracer, was developed by modifying the chemical structure of [F]THK5351.
View Article and Find Full Text PDFDiscovery and preclinical development of [F]ACI‐19626, a first‐in‐class TDP‐43 PET tracer.
Alzheimers Dement
December 2024
AC Immune, Lausanne, Vaud, Switzerland
Background: Aggregated TDP‐43 is found as the main component of pathological inclusions in amyotrophic lateral sclerosis (ALS), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE), in 50% of patients with frontotemporal dementia (FTD), and is present as co‐pathology in other neurodegenerative diseases, including Alzheimer’s disease (AD). Biofluid or imaging biomarkers of TDP‐43 pathology are currently unavailable. Direct detection of TDP‐43 aggregates holds promise for unraveling the pathobiology of disease and for enabling precision medicine approach via improved diagnosis, patient stratification and assessment of therapeutic efficacy in clinical trials in AD and related diseases.
View Article and Find Full Text PDF[F]SMBT‐1 PET can visualize the spatial distribution of reactive astrogliosis in patients with neurodegenerative dementias.
Alzheimers Dement
December 2024
CYRIC, Tohoku University, Sendai, Japan
Background: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO‐B) are used to visualize reactive astrogliosis in the living brain. [18F]SMBT‐1, a MAO‐B selective PET tracer, was developed by modifying the chemical structure of [18F]THK5351.
View Article and Find Full Text PDFEffect Of Horseradish (Moringa Oleifera) Seeds on Biochemical and Molecular Parameters in Paraquat‐Induced Parkinson Disease‐Like Symptoms in Fruit Flies.
Alzheimers Dement
December 2024
Federal University of Technology, Akure, Ondo, Nigeria
Background: In recent decades, epidemiological and experimental studies have looked into the role of pesticides, particularly the herbicide paraquat, in the development of Parkinson’s disease. Horseradish tree ( is an ethnobotanical plant with lots of therapeutic potential, but there is a dearth of information on the bioactive properties of the seed alkaloid extracts.
Method: This study examined the modulatory effects of various concentrations of an alkaloid extract from the seeds of Horseradish Tree () on the survival rate of flies exposed to paraquat, as well as certain biochemical and molecular markers related to Parkinson’s disease in the heads of the flies.
Effects of combination mixture of with psychoactive drugs on adenosine deaminase, ectonucleosides enzymes, redox status, cognition and hemodynamic function in male rats.
Alzheimers Dement
December 2024
Federal University of Technology Akure, Ondo State, Akure, Nigeria
Background: The effect of high consumption of psychoactive substances of codeine (CDE), tramadol (TMD), and (CNB) as concoction has been associated with altered brain cognitive and neurochemical functions. However, the understanding of the complex mechanism behind the intake of co‐administration with tramadol and codeine on both cardiac and brain function, neurotransmitters, purinergic, and antioxidant enzymes activities in the brain and heart of rats remains unreported.
Method: The measure of cognition using morris water maze (MWM) and Y‐maze tests, hemodynamic parameters namely systolic blood pressure (SBP) and heart rate (HR), acetylcholinesterase (AChE), butyl‐cholinesterase (BCHE), adenosine deaminase (ADA), arginase, catalase (CAT), superoxide dismutase (SOD) enzymes’ activities, reduced glutathione (GSH) and malondialdehyde (MDA), nitric oxide (NO) levels, in the brain and heart of CNB, TMD, and CDE exposed rats was done.
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