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Prediction of urine culture results by automated urinalysis with digital flow morphology analysis. | LitMetric

Prediction of urine culture results by automated urinalysis with digital flow morphology analysis.

Sci Rep

Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro Gangnam-gu, Seoul, 06273, South Korea.

Published: March 2021

AI Article Synopsis

  • The study aimed to explore how urinalysis results relate to urine cultures and to create a prediction model, named the UTOPIA value, based on this relationship.
  • It included 42,713 patients, dividing them into training and test datasets, and developed the UTOPIA value using several key variables linked to a higher risk of urinary tract infections (UTIs).
  • The UTOPIA value showed a strong diagnostic performance (area under the curve of 0.837) in predicting urine culture results, potentially minimizing unnecessary culture testing in clinical settings.

Article Abstract

To investigate the association between the results of urinalysis and those of concurrent urine cultures, and to construct a prediction model for the results of urine culture. A total of 42,713 patients were included in this study. Patients were divided into two independent groups including training and test datasets. A novel prediction algorithm, designated the UTOPIA value, was constructed with the training dataset, based on an association between the results of urinalysis and those of concurrent urine culture. The diagnostic performance of the UTOPIA value was validated with the test dataset. Six variables were selected for the equation of the UTOPIA value: age of higher UTI risk [odds ratio (OR), 2.069125], female (OR, 1.400648), nitrite (per 1 grade; OR, 3.765457), leukocyte esterase (per 1 grade; OR, 1.701586), the number of WBCs (per 1 × 10/L; OR, 1.000121), and the number of bacteria (per 1 × 10/L; OR, 1.004195). The UTOPIA value exhibited an area under the curve value of 0.837 when validated with the independent test dataset. The UTOPIA value displayed good diagnostic performance for predicting urine culture results, which would help to reduce unnecessary culture. Different cutoffs can be used according to the clinical indication.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966378PMC
http://dx.doi.org/10.1038/s41598-021-85404-1DOI Listing

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