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Effect of high-fat diet on IgA cells and BAFF/APRIL in small intestinal villous lamina propria of mice.
Cell Immunol
January 2025
Faculty of Health Sciences, Department of Rehabilitation, Health Science University, 7187 Kodachi, Fujikawaguchiko-Machi, Minamitsuru-Gun, Yamanashi, Japan. Electronic address:
Obesity exacerbates susceptibility to infectious diseases. We investigated the effects of a high-fat diet (HFD) on intestinal immunity, particularly immunoglobulin (Ig)A-producing cells, B-cell activating factor (BAFF), and a proliferation-inducing ligand (APRIL) localization. Mice (4- to 20-weeks old) were fed HFD or standard chow diet, and their jejunum and ileum were fixed using the in vivo cryotechnique.
View Article and Find Full Text PDFImmune cells mediated the causal relationship between the gut microbiota and anxiety disorders: A Mendelian randomization study.
J Affect Disord
January 2025
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. Electronic address:
Background: Studies have demonstrated that the gut microbiome-immune system-brain axis plays an important role in neurological disorders. Furthermore, recent studies have shown that the gut microbiota influences the occurrence and progression of anxiety disorders, with potential involvement of immune cells. We aimed to investigate the causal impact of gut microbiota on anxiety disorders and identify potential immune cell mediators.
View Article and Find Full Text PDFComparative Analysis of Serum BAFF and IL-17 Levels Pre- and Post-Antipsychotic Treatment for Acute Schizophrenia.
Int J Mol Sci
January 2025
Research Laboratory LR12ES04, Faculty of Medicine of Sousse, University of Sousse, Sousse 4002, Tunisia.
The interplay between the cytokine network and antipsychotic treatment in schizophrenia remains poorly understood. This study aimed to investigate the impact of psychotropic medications on serum levels of IFN-γ, IL-4, TGF-β1, IL-17, and BAFF, and to explore their relationship with psychopathological features. We recruited 63 patients diagnosed with schizophrenia in the acute phase, all of whom were either drug-naïve or had been drug-free for at least three months.
View Article and Find Full Text PDFCommentary: BAFF blockade attenuates DSS-induced chronic colitis inhibiting NLRP3 inflammasome and NF-кB activation.
Front Immunol
December 2024
School of Medicine, Shenzhen University, Shenzhen, China.
Neuro-Behçet's disease: an update of clinical diagnosis, biomarkers, and immunopathogenesis.
Clin Exp Immunol
January 2025
Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Neuro-Behçet's disease (NBD) is a more severe but rare symptom of Behçet's disease, which is mainly divided into parenchymal NBD (p-NBD) involving brain stem, spinal cord, and cerebral cortex. Non-p-NBD manifests as intracranial aneurysm, cerebral venous thrombosis, peripheral nervous system injuries, and mixed parenchymal and non-parenchymal disease. p-NBD is pathologically characterized by perivasculitis presenting with cerebrospinal fluid (CSF) pleocytosis, elevated total protein, and central nervous system (CNS) infiltration of macrophages and neutrophils, which are subdivided into acute and chronic progressive stages according to relapsing-remitting courses and responses to steroids.
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