AI Article Synopsis
- The study investigated cytokine levels (IL-1β, CXCL8, TNF-α) in the peri-implant sulcular fluid (PISF) of patients without mucositis or peri-implantitis, comparing them to levels in gingival crevicular fluid (GCF) from patients with healthy gums and varying stages of periodontitis.
- Results showed that IL-1β and CXCL8 were significantly lower in PISF than in GCF from periodontitis patients, while TNF-α was higher in PISF than in those with healthy gums and mild periodontitis.
- The findings suggest that monitoring these cytokine levels could aid in understanding and diagnosing peri-implantitis, especially in
Article Abstract
Background: Our study aimed to assess the level of IL-1β, CXCL8, and TNF-α in peri-implant sulcular fluid (PISF) collected from patients with no clinical symptoms of mucositis or peri-implantitis and compare them with cytokine concentration in gingival crevicular fluid (GCF) acquired from patients with healthy periodontium and those with varying severity of periodontitis.
Methods: A total of 189 subjects were included in the study, and GCF/PISF samples were checked for IL-1β, CXCL8, and TNF-α levels using an ELISA test.
Results: The IL-1β level in PISF in patients with implants was significantly lower than in GCF in patients with mild, moderate, or severe periodontitis. The CXCL8 level in PISF was considerably lower than in patients with moderate periodontitis. The TNF-α level in PISF in patients with implants was markedly higher compared to subjects with healthy periodontium or patients with mild periodontitis.
Conclusion: Analysis of cytokine levels may help describe the pathogenesis and early diagnosis of peri-implantitis and prevision in high-risk patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968186 | PMC |
| http://dx.doi.org/10.1186/s12903-021-01478-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!