Although deeper convolutional neural networks (CNNs) generally obtain better performance on classification tasks, they incur higher computation costs. To address this problem, this study proposes the optronic convolutional neural network (OPCNN) in which all computation operations are executed in optics, and data transmission and control are executed in electronics. In OPCNN, we implement convolutional layers with multi input images by the lenslet 4f system, downsampling layers by optical-strided convolution and obtaining nonlinear activation by adjusting the camera's curve and fully connected layers by optical dot product. The OPCNN demonstrates good performance on the classification tasks in simulations and experiments and achieves better performance than other current optical convolutional neural networks by comparison due to the more complex architecture. The scalability of OPCNN contributes to building deeper networks when facing complicated datasets.
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http://dx.doi.org/10.1364/OE.415542 | DOI Listing |
Brain Struct Funct
January 2025
Department of Biomedical Engineering, College of Chemistry and Life Sciences, Beijing University of Technology, Beijing, 100124, China.
The brain undergoes atrophy and cognitive decline with advancing age. The utilization of brain age prediction represents a pioneering methodology in the examination of brain aging. This study aims to develop a deep learning model with high predictive accuracy and interpretability for brain age prediction tasks.
View Article and Find Full Text PDFToxicol Pathol
January 2025
Charles River Laboratories, Edinburgh, UK.
Thyroid tissue is sensitive to the effects of endocrine disrupting substances, and this represents a significant health concern. Histopathological analysis of tissue sections of the rat thyroid gland remains the gold standard for the evaluation for agrochemical effects on the thyroid. However, there is a high degree of variability in the appearance of the rat thyroid gland, and toxicologic pathologists often struggle to decide on and consistently apply a threshold for recording low-grade thyroid follicular hypertrophy.
View Article and Find Full Text PDFBMC Bioinformatics
January 2025
Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.
J Imaging Inform Med
January 2025
Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat, 10000, Morocco.
Gastrointestinal (GI) disease examination presents significant challenges to doctors due to the intricate structure of the human digestive system. Colonoscopy and wireless capsule endoscopy are the most commonly used tools for GI examination. However, the large amount of data generated by these technologies requires the expertise and intervention of doctors for disease identification, making manual analysis a very time-consuming task.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303. Electronic address:
Polysorbate 20 (PS20) is commonly used as an excipient in therapeutic protein formulations. However, over the course of a therapeutic protein product's shelf life, minute amounts of co-purified host-cell lipases may cause slow hydrolysis of PS20, releasing fatty acids (FAs). These FAs may precipitate to form subvisible particles that can be detected and imaged by various techniques, e.
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