We report on the design and automation of a mid-infrared, continuous wave, singly-resonant optical parametric oscillator. Hands-free controls and the implementation of a tuning algorithm allowed for hundreds of nanometers of continuous, effective-mode-hop-free tuning over the range of 2190-4000 nm. To demonstrate the applicability of this light source and algorithm to mid-IR spectroscopy, we performed a sample spectroscopy measurement in a CH gas cell and compared the experimentally-measured absorption spectrum to HITRAN 2016 simulations. We found excellent agreement with simulation in both peak heights and peak centers; we also report a reduced uncertainty in peak centers compared to simulation.
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http://dx.doi.org/10.1364/OE.418287 | DOI Listing |
Biosens Bioelectron
January 2025
Institute of Physics, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland.
Fabry disease (FD) is a rare disorder resulting from a genetic mutation characterized by the accumulation of sphingolipids in various cells throughout the human body, leading to progressive and irreversible organ damage, particularly in males. Genetically-determined deficiency or reduced activity of the enzyme (alpha - Galactosidase; α-Gal) leads to the accumulation of sphingolipids in the lysosomes of various cell types, including the heart, kidneys, skin, eyes, central nervous system, and digestive system, triggering damage, leading to the failure of vital organs, and resulting in progressive disability and premature death. FD diagnostics currently depend on costly and time-intensive genetic tests and enzymatic analysis, often leading to delayed or inaccurate diagnoses, which contribute to rapid disease progression.
View Article and Find Full Text PDFSci Adv
December 2024
Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Most molecules and dielectric materials have characteristic bond vibrations or phonon modes in the mid-infrared regime. However, infrared absorption spectroscopy lacks the sensitivity for detecting trace analytes due to the low quantum efficiency of infrared sensors. Here, we report mid-infrared photothermal plasmonic scattering (MIP-PS) spectroscopy to push the infrared detection limit toward nearly a hundred molecules in a plasmonic nanocavity.
View Article and Find Full Text PDFAppl Spectrosc
December 2024
Research Division of Environmental Analytics, Process Analytics and Sensors, Institute of Chemical Technologies and Analytics, TU Wien, Vienna, Austria.
Volatile organic compounds (VOCs) are an ever-growing hazard for health and environment due to their increased emissions and accumulation in the air. Quantum cascade laser-based infrared (QCL-IR) sensors hold significant promise for gas monitoring, thanks to their compact, rugged design, high laser intensity, and high molecule-specific detection capabilities within the mid-infrared spectrum's fingerprint region. In this work, tunable external cavity QCLs were complemented by an innovative germanium-on-silicon integrated optics waveguide sensing platform with integrated microlenses for efficient backside optical interfacing for the tunable laser spectrometer.
View Article and Find Full Text PDFPhotoacoustics
December 2024
ASI Agenzia Spaziale Italiana - Centro di Geodesia Spaziale, Località Terlecchia, Matera, 75100, Italy.
Nowadays, the scientific community and industry are increasingly pressed to provide solutions for developing compact and highly-performing trace-gas sensors for several applications of crucial importance, such as environmental monitoring or medical diagnostics. In this context, this work describes a novel configuration, making use of a mid-IR spectrophone combining the compactness of a photo-acoustic setup, a non-conventional micro-electro-mechanical (MEMS) acousto-to-voltage transducer, and the sensitivity enhancement given by a cost-effective and easy-to-build dual-tube resonator configuration. In the optimal condition of sample pressure, the system developed in this work can achieve a minimum detection limit (MDL) equal to 0.
View Article and Find Full Text PDFJ Chem Phys
December 2024
Center for Engineering Concepts Development, Department of Mechanical Engineering, University of Maryland at College Park, College Park, Maryland 20742, USA.
In this paper, we develop a model based on a second quantization-with anharmonic phonon scattering and the phonon Boltzmann transport equation-to study precise high-resolution nonequilibrium vibrational energy transfer (VET) under selective phonon excitation in cyclotrimethylene trinitramine. We simulate mid-infrared pump-probe spectroscopy and observe a prompt appearance (<1 ps) of broad-spectrum intensity, which agrees well with experimental data in the literature. The selective excitation of phonons at different frequencies reveals distinct VET pathways and the kinetic evolution of mode occupations as the system reaches a new equilibrium temperature.
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