AI Article Synopsis
- The intravitreal dexamethasone (IV-DEX) implant is generally effective for macular edema, but its effectiveness in silicone oil (SO)-filled eyes is debated.
- A 72-year-old man with complicated diabetic retinopathy experienced persistent macular edema despite various treatments, including IV-DEX in an SO context.
- Ultimately, the removal of silicone oil followed by a second IV-DEX implant successfully reduced the macular edema, suggesting that IV-DEX may not work as well in eyes filled with silicone oil compared to those with normal vitreous.
Article Abstract
Rationale: An intravitreal dexamethasone (IV-DEX) implant is safe and effective for the treatment of macular edemas; however, the efficacy of IV-DEX implants in silicone oil (SO)-filled eyes remains controversial. There is no previous study comparing an IV-DEX implant in the same eye with and without intravitreal SO.
Patient Concerns: A 72-year-old man with proliferative diabetic retinopathy, macular edema, and rhegmatogenous retinal detachment, treated with pars plana vitrectomy with SO tamponade had refractory macular edema.
Diagnosis: Refractory macular edema.
Intervention: Subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation were performed; this was followed by intravitreal SO removal combined with IV-DEX implantation.
Outcomes: The macular edema did not decrease significantly with posterior subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation; however, the edema was relieved after SO removal and a new IV-DEX implantation.
Lessons: IV-DEX implant may be less efficacious in the treatment of macular edema in an SO-filled eye than that in a normal vitreous cavity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982211 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000025161 | DOI Listing |
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Article Synopsis
- The intravitreal dexamethasone (IV-DEX) implant is generally effective for macular edema, but its effectiveness in silicone oil (SO)-filled eyes is debated.
- A 72-year-old man with complicated diabetic retinopathy experienced persistent macular edema despite various treatments, including IV-DEX in an SO context.
- Ultimately, the removal of silicone oil followed by a second IV-DEX implant successfully reduced the macular edema, suggesting that IV-DEX may not work as well in eyes filled with silicone oil compared to those with normal vitreous.
Evaluation of Safe Systemic Immunosuppression Created with Dexamethasone in Prevention of Capsular Contracture: A Glance to Distinct Perspectives with Toll-Like Receptors.
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August 2018
Istanbul Okmeydani Training and Research Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, 34384, Istanbul, Turkey.
Purpose: The toll-like receptors (TLRs) stand at the interface of innate immune activation. We hypothesize to decrease the response of innate immunity activated by TLR4 by a safe, short-term, systemic immunosuppression.
Methods: Two silicone block implants were placed into two dorsal subcutaneous pockets in 32 rats that were subdivided into four groups: The two study groups were the IV DEX group (single intravenous injection of dexamethasone 1 h before surgery) and the IV DEX + IP DEX group (in addition to a single intravenous injection of dexamethasone 1 h before surgery, intraperitoneal dexamethasone was administered for 10 days after surgery), and the two control groups were the untreated control group and the saline-treated control group.
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