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The evaluation of oxidative stress parameters in breast and colon cancer. | LitMetric

AI Article Synopsis

  • The study explored the link between ischemia modified albumin (IMA) levels and various oxidative stress markers in breast cancer (BC) and colon cancer (CC) patients compared to healthy controls, finding significant differences in these levels between groups.
  • Results showed that cancer patients had higher oxidative stress markers (like protein carbonyls and malondialdehyde) and lower antioxidant levels than controls, with specific distinctions between breast and colon cancer patients.
  • IMA levels correlated with tumor size and metastatic characteristics in the cancer groups, suggesting that oxidative stress plays a significant role in cancer development, and IMA could serve as a secondary diagnostic biomarker.

Article Abstract

Our aim in this study was to investigate the relationship between serum ischemia modified albumin (IMA) levels with oxidative stress parameters [protein carbonyl (PCO), advanced protein oxidation products (AOPPs), malondialdehyde (MDA), total nitric oxide (NOx), prooxidant-antioxidant balance (PAB), and ferric reducing of antioxidant power (FRAP)] in breast cancer (BC) and colon cancer (CC).In total, 90 patients undergoing surgical treatment for BC (n = 45) or CC (n = 45) and 35 healthy controls were included in this cross-sectional study.The serum PCO, AOPPs, MDA, NOx, PAB, and IMA levels were all statistically significantly higher in the cancer patients than in the control group. MDA, NOx, and PAB levels were significantly lower in the BC group than in the CC group. FRAP values were statistically significantly lower in both the CC group and the BC group compared to the control. IMA showed a weak positive correlation with CA-19.9 (r = 0.423 P = .007) but a moderate positive correlation with tumor size in the CC group. IMA showed a positive correlation with metastasis, grade, and HER2 and a negative correlation with ER and PR in the BC group.Oxidative stress is a key player in the development of solid malignancies. Cancer development is a multistage process, and oxidative stress caused by the production of ROS/RNS in the breast and colon may predispose individuals to BC and CC. Patients with BC and CC had an impaired oxidative/antioxidant condition that favored oxidative stress. The ROC analysis indicated that IMA sensitivity above 80% could be used as a secondary biomarker in diagnosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982186PMC
http://dx.doi.org/10.1097/MD.0000000000025104DOI Listing

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