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Ther Innov Regul Sci

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Department of Regulatory and Quality Sciences, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, USA.

Background: Youth nicotine addiction is a major public health concern in the United States. Disposable Electronic Nicotine Delivery Systems (ENDS), or disposable vapes, are commonly sought out by youth despite not having received premarket authorization from the FDA. The objective of this study was to identify factors contributing to underage consumption of disposable ENDS.

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  • Disposable e-cigarettes are the most popular choice among youth in the US, but there is limited data on their characteristics in the online market.
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Puff Bar, a disposable electronic nicotine delivery system (ENDS), was the ENDS brand most commonly used by U.S. youth in 2021.

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Physical and Chemical Characterization of Aerosols Produced from Commercial Nicotine Salt-Based E-Liquids.

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Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States.

Nicotine salt e-liquids are widely used in pod-style and disposable electronic nicotine delivery systems (ENDS). Studying the physical and chemical properties of their emissions can inform their toxicological impact. A prior companion study reported the harmful and potentially harmful constituents (HPHCs) and aerosol particle sizes produced from laboratory-made nicotine salt and freebase nicotine e-liquids to assess the effects of varying nicotine salts and nicotine protonation.

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