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Gibberellin-Regulated Protein allergy may identify cypress pollen related fruit allergy with negative test to peach.
J Allergy Clin Immunol Pract
January 2025
Immunology Unit, Verona University Hospital, Verona, Italy. Electronic address:
If a cypress-sensitized patient experiences severe reactions to fruits-particularly with periorbital angioedema and cofactors present-consider testing for Pru p 7-specific IgE, even if initial tests, such as specific IgE to peach and SPT with peach extract, are negative.
View Article and Find Full Text PDFPeach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients.
Allergol Int
December 2024
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan. Electronic address:
Background: Component-resolved diagnostics are used to diagnose food allergies. Currently, reports on sensitization profiles using peach-allergen components in a multicenter setting are lacking. In this study, sensitization profiling of peach allergy was performed to evaluate the clinical utility of each component specific-immunoglobulin E antibody (sIgE ab) test.
View Article and Find Full Text PDFIs gastrointestinal epithelial barrier dysfunction the only responsible for sensitization to food allergens?
Eur Ann Allergy Clin Immunol
November 2024
Clinical and Laboratory Molecular Allergy Unit, Fondazione Luigi Maria Monti, IDI-IRCCS, Rome, Italy.
Article Synopsis
- Epithelial barriers are vital for protecting against pathogens and allergens, and when environmental factors compromise them, conditions like asthma and food allergies can arise.
- While the dysfunction of skin and respiratory barriers in allergies is well-established, the gut epithelium's role in food allergies is less clear, as it usually maintains integrity and fosters immune tolerance through specific immune mechanisms.
- Research indicates that certain food allergies, such as those to cow's milk and hen's egg, often resolve with age, and studies like the LEAP trial suggest that early allergen exposure can help prevent allergies, showcasing the complex nature of allergen sensitization beyond just food intake.
Screening of IgE-Binding Epitopes of Peach Allergenic Protein Pru p 7 Based on an Immune Microarray Assay.
J Agric Food Chem
October 2024
Chinese Academy of Inspection and Quarantine, Beijing 100176, People's Republic of China.
Pru p 7 (also named Peamaclein) is a member of the gibberellin-regulated protein family, which is the latest foodborne allergenic protein identified in peach. In this paper, the prokaryotic expression and identification of Pru p 7 were performed, and the protein properties, structure, and homology were analyzed. In addition, a preliminary screening of B-cell linear epitopes of Pru p 7 was performed by the bioinformatics software prediction method, and three epitopes were identified using slot-blot immune microarray assay combined with an immune score matrix (P-1, AA16-21, AGYQER; P-2, AA40-46, TYGNKDE; P-3, AA52-59, DLKNSKGN).
View Article and Find Full Text PDFGibberellin-regulated protein allergy and orange-induced anaphylaxis.
Allergol Immunopathol (Madr)
September 2024
Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya, Sakarya University, Medical Faculty, Adapazarı, Sakarya, Türkiye;
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