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| http://dx.doi.org/10.1007/s00101-021-00937-4 | DOI Listing |
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Case Report: Painful left bundle branch block syndrome complicated with vasovagal syncope.
Front Cardiovasc Med
January 2025
Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Background: Painful left bundle branch block (LBBB) syndrome is an uncommon disease that is defined as intermittent episodes of angina associated with simultaneous LBBB changes on an electrocardiogram (ECG) with the absence of flow-limiting coronary artery disease or ischemia on functional testing. Vasovagal syncope (VVS) is the most common cause of syncope and can be provoked by sublingual nitroglycerin (NTG). Herein, we report a case of painful LBBB syndrome complicated with VVS, which was misdiagnosed as acute coronary syndrome and cardiogenic shock.
View Article and Find Full Text PDFReduced contrast agent volume using a heart-rate dependent and free-breathing scanning protocol in coronary computed tomography angiography (CTA) for patients with chronic obstructive pulmonary disease (COPD).
BMC Cardiovasc Disord
January 2025
Department of Radiology, Central Hospital Affiliated to Shandong First Medical University, Jinan City, Shandong Province, China.
Background: The personalized, free-breathing, heart rate-dependent computed tomography angiography (CTA) protocol can significantly reduce the utilization of contrast medium (CM). This proves especially beneficial for patients with chronic obstructive pulmonary disease (COPD) undergoing coronary artery CTA examinations.
Objective: The aim of this study was to evaluate the feasibility of a personalized CT scanning protocol that was tailored to patients' heart rate and free-breathing for coronary CTA of patients with COPD.
Rate dependent complete right bundle block: a challenging diagnosis in Brugada syndrome.
Eur Heart J
December 2024
Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 of Litang Road, Beijing 102218, China.
A novel computational model of swine ventricular myocyte reveals new insights into disease mechanisms and therapeutic approaches in Timothy Syndrome.
Sci Rep
November 2024
Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Timothy syndrome type 1 (TS1), a malignant variant of Long QT Syndrome, is caused by L-type Ca2+ Channel (LTCC) inactivation defects secondary to the p.Gly406Arg mutation in the CACNA1C gene. Leveraging on the experimental in vitro data from our TS1 knock-in swine model and their wild-type (WT) littermates, we first developed a mathematical model of WT large white swine ventricular cardiomyocyte electrophysiology that reproduces a wide range of experimental data, including ionic current properties, action potential (AP) dynamics, and handling.
View Article and Find Full Text PDFCardiac functional assessment using prospectively electrocardiography-triggered computed tomography in children with congenital heart disease: Comparison of radiation dose and image quality between heart rate-dependent single-extended and heart rate-independent dual-focused scans.
Eur J Radiol
January 2025
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Article Synopsis
- The study aimed to assess the radiation dose reduction potential of a heart rate-independent dual-focused scan method for CT imaging in children with congenital heart disease (CHD), comparing it to traditional heart rate-dependent scans.
- It involved 1,252 pediatric CT exams, using propensity score matching to control for age and sex while analyzing CT radiation dose, image noise, and quality metrics.
- Results showed that dual-focused and single-extended scans had higher radiation doses compared to single-focused scans, but achieved similar image quality, with the dual-focused option being more effective at lower heart rates.
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