What factors explain spatial variation in the severity of COVID-19 across the United States? To answer this question, we analyze the correlates of COVID-19 cases and deaths across US counties. We document four sets of facts. First, effective density is an important and persistent determinant of COVID-19 severity. Second, counties with more nursing home residents, lower income, higher poverty rates, and a greater presence of African Americans and Hispanics are disproportionately impacted, and these effects show no sign of disappearing over time. Third, the effect of certain characteristics, such as the distance to major international airports and the share of elderly individuals, dies out over time. Fourth, Trump-leaning counties are less severely affected early on, but later suffer from a large severity penalty.
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http://dx.doi.org/10.1016/j.jue.2021.103332 | DOI Listing |
PLoS Negl Trop Dis
January 2025
The Centre for Health Informatics, Computing, and Statistics (CHICAS), Lancaster Medical School, Lancaster University, Lancaster, United Kingdom.
Background: The Expanded Special Project for the Elimination of Neglected Tropical Diseases (ESPEN) was launched in 2019 by the World Health Organization and African nations to combat Neglected Tropical Diseases (NTDs), including Soil-transmitted helminths (STH), which still affect over 1.5 billion people globally. In this study, we present a comprehensive geostatistical analysis of publicly available STH survey data from ESPEN to delineate inter-country disparities in STH prevalence and its environmental drivers while highlighting the strengths and limitations that arise from the use of the ESPEN data.
View Article and Find Full Text PDFBackground: The full pentavalent (DPT-HepB-Hib) vaccination is the main strategy to prevent five communicable diseases in early childhood, especially in countries with huge communicable disease burdens like Ethiopia. Exploring spatial distributions and determinants of full pentavalent vaccination status in minor ecological areas in Ethiopia is crucial for creating targeted immunization campaigns and monitoring the advancement of accomplishing sustainable development goals. This study aimed to investigate the spatial disparities and determinants of full pentavalent vaccination among 12-23-month-old children in Ethiopia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Alzheimer's Disease can present with heterogenous neurodegenerative patterns. In order to optimize clinical trials and personalized medicine, the identification and characterization of diverse pathological brain patterns associated with AD have become paramount. Optimal approaches to identify such heterogeneity are unknown.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Background: Regional cerebral blood flow (CBF) can be noninvasively quantified using arterial spin labeled (ASL) perfusion MRI. In Alzheimer's disease (AD) and mild cognitive impairment (MCI), hypoperfusion typically occurs in precuneus, posterior cingulate cortex (PCC), and hippocampus. Small vessel disease (SVD), a systemic disorder that commonly underlies vascular cognitive impairment, also causes brain hypoperfusion.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Università degli studi di Genova, Genova, Liguria, Italy.
Background: Alzheimer's disease (AD) is the most common form of dementia, predominantly manifesting as amnestic impairment. However, atypical presentations such as logopenic variant of primary progressive aphasia (lvPPA), posterior cortical atrophy (PCA), corticobasal syndrome (CBS) and frontal AD pose diagnostic challenges. This study presents preliminary data from a retrospective analysis investigating brain functional differences between typical and atypical AD forms.
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