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Key characteristics of carcinogens meet hallmarks for prevention-cutting the Gordian knot.
Front Oncol
September 2024
Agency for Prevention, Environment and Energy, Emilia-Romagna (Arpae), Bologna, Italy.
The complexity of cancer requires a comprehensive approach to understand its diverse manifestations and underlying mechanisms. Initially outlined by Hanahan and Weinberg in 2000 and updated in 2010, the hallmarks of cancer provide a conceptual basis for understanding inherent variability in cancer biology. Recent expansions have further elucidated additional hallmarks, including phenotypic plasticity and senescent cells.
View Article and Find Full Text PDFCutting the Gordian Knot: Rare Presentation of Nodular Fasciitis as Supraclavicular Swelling with Muscular Involvement in Ga-FAPI-PET/CT.
Diagnostics (Basel)
October 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66421 Homburg, Germany.
Nodular fasciitis is a benign, singularly occurring nodular fibroblastic/myofibroblastic neoplasia. Due to the rapid growth and cellular atypia, this rare differential diagnosis in the head and neck region can be mistaken for malignant sarcomas. We present a 40-year-old female patient with an unclear, rough, and poorly displaceable supraclavicular swelling on the right as part of a medical check-up.
View Article and Find Full Text PDFCutting the Gordian knot of diuretic resistance using continuous ultrafiltration in a Holt-Oram patient with decompensated heart failure and Eisenmenger syndrome: a case report.
Eur Heart J Case Rep
August 2024
First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University, Vasilisis Sofias 114, 11527 Athens, Greece.
Background: Continuous ultrafiltration consists a decongestion method for patients with refractory decompensated heart failure with diuretic resistance as it enables the energetic withdrawal of isotonic fluid under controlled rate according to the patient's vital signs, offering decongestion without exceeding plasma refill rate.
Case Summary: A 62-year-old male with history of Holt-Oram syndrome with Eisenmenger physiology presented with worsening dyspnoea. Patient initial clinical and laboratory examination, renal vein ultrasound, and echocardiogram were consistent with significant congestion.
Cutting the Gordian knot of neutrophil extracellular traps research.
J Thromb Haemost
September 2024
Department of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address:
Untangling the Gordian Knot of sea hare egg masses: An integrated open-hardware system for standardized egg strand sizing and packaging for cryopreservation research and application.
HardwareX
December 2023
Aquatic Germplasm and Genetic Resources Center (AGGRC), School of Renewable Natural Resources, Louisiana State University Agricultural Center, Baton Rouge, LA 70820, United States.
The California sea hare () provides a powerful biomedical model system for studying aspects of neurological development and damage, behavior, aging, and hypoxia. encapsulate their zygotes within strands that result in tangled egg masses that greatly complicate culture and experimentation. The historical and current importance of for biomedical research and the mounting climate crisis necessitates protection of genetic resources.
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