AI Article Synopsis
- The study focuses on designing a biodegradable encapsulation system using synthetic peptides to encapsulate perfluorinated hydrocarbons, with applications as artificial blood substitutes.
- A specific diblock-peptide, Bu-PAsp-PPhe, was synthesized and characterized, enabling it to self-assemble with perfluorodecalin (PFD) into spherical capsules.
- These capsules, measuring about 360 nm in diameter, demonstrate the ability to efficiently uptake and release oxygen, making them potential candidates for safe, biodegradable oxygen carriers in medical applications.
Article Abstract
The design of an encapsulation system consisting of a synthetic peptide which is fully biodegradable into non-toxic constituents. This system should be capable of encapsulating perfluorinated hydrocarbons and should be a promising basis for oxygen carriers to be used as artificial blood replacement. A diblock-peptide is synthesised following a phosgene-free method and characterised by H-NMR. Subsequently, this diblock-peptide is self-assembled with perfluorodecalin (PFD) to form PFD-filled capsules as potential artificial oxygen carriers allowing for rapid oxygen uptake and release. The diblock-peptide Bu-PAsp-PPhe is successfully synthesised and used to encapsulate PFD. The capsules have a spherical shape with an average diameter of 360 nm in stable aqueous dispersion. NMR measurements prove their physical capability for reversible uptake and release of oxygen. The resulting capsules are expected to be fully biodegradable and possibly could act as oxygen carriers for artificial blood replacement.
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| http://dx.doi.org/10.1080/02652048.2021.1903594 | DOI Listing |
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