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Circadian variations of vasoconstriction and blood pressure in physiology and diabetes. | LitMetric

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes.

Curr Opin Pharmacol

Department of Physiology, University of Kentucky, College of Medicine, USA; Saha Cardiovascular Research Center, University of Kentucky, College of Medicine, USA. Electronic address:

Published: April 2021

AI Article Synopsis

Article Abstract

The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164980PMC
http://dx.doi.org/10.1016/j.coph.2021.02.001DOI Listing

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