The HIV cascade model can be used as an epidemiological surveillance tool and for assessing the quality of medical care for HIV-positive people. It is possible to use the model for the entire population of people living with HIV, in various socio-demographic groups, by region, years and other indicators. This article describes the features of a HIV cascade model depending on the goals for its use.
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http://dx.doi.org/10.26442/00403660.2020.11.000686 | DOI Listing |
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January 2025
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P.R. China.
Nanozymes open up new avenues for amplifying signals in photoelectrochemical (PEC) biosensing, which are yet limited by the generated small-molecule signal reporters. Herein, a multifunctional nanoenzyme of Pt NPs/CoSAs@NC consisting of Co single atoms on N-doped porous carbon decorated with Pt nanoparticles is successfully synthesized for cascade catalytic polymerization of dopamine for constructing a highly sensitive photocurrent-polarity-switching PEC biosensing platform. Taking protein tyrosine phosphatase 1B (PTP1B) as a target model, Pt NPs/CoSAs@NC nanoenzymes are linked to magnetic microspheres via phosphorylated peptides.
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December 2024
School of Naval Architecture, Ocean and Energy Power Engineering, Wuhan University of Technology, Wuhan 430063, China.
Solar photovoltaic (PV) conversion has become a key area in today's energy supply. However, incomplete utilization of the PV cell bandgap results in the conversion of photon energy outside the bandgap into waste heat, reducing the overall efficiency. Improving spectral utilization efficiency and mitigating the effects of PV waste heat are top priorities.
View Article and Find Full Text PDFMol Oncol
January 2025
Sarcoma Research Group, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Oncobell, L'Hospitalet de Llobregat, Barcelona, Spain.
Ewing sarcoma (EWS) is the second most common bone tumor affecting children and young adults, with dismal outcomes for patients with metastasis at diagnosis. Mechanisms leading to metastasis remain poorly understood. To deepen our knowledge on EWS progression, we have profiled tumors and metastases from a spontaneous metastasis mouse model using a multi-omics approach.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
The Hebrew University of Jerusalem - Givat Ram Campus: Hebrew University of Jerusalem - Edmond J Safra Campus, Institute of Chemistry, Givat Ram, 91904, Jerusalem, ISRAEL.
A method to photomodulate dynamically transient DNA-based reaction circuits and networks is introduced. The method relies on the integration of photoresponsive o-nitrobenzyl-phosphate ester-caged DNA hairpin with a "mute" reaction module. Photodeprotection (λ = 365 nm) of the hairpin structure separates a fuel strand triggering the dynamic, transient, operation of the DNA circuit/network.
View Article and Find Full Text PDFNeurosci Biobehav Rev
January 2025
Department of Pharmaceutical Sciences, Faculty of Life Sciences, Gurugram University (A State Govt. University), Gurugram, Haryana, India. Electronic address:
Plexins are a family of transmembrane receptors known for their diverse roles in neural development, axon guidance, neuronal migration, synaptogenesis, and circuit formation. Semaphorins are a class of secreted and membrane proteins that act as primary ligands for plexin receptors. Semaphorins play a crucial role in central nervous system (CNS) development by regulating processes such as axonal growth, neuronal positioning, and synaptic connectivity.
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