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Topical fluoride varnish application shifts dysbiotic dental plaque microbiome towards eubiosis in children with dental caries.
Saudi Dent J
October 2024
School of Dentistry, The University of Queensland, Australia.
Objective: This study used high-throughput amplicon sequencing to examine the impact of long-term continuous fluoride treatment on the dental plaque microbiota of children aged 8 to 9 with mixed dentition.
Design: The study population consisted of twenty 8-9-year-old children with dental caries. Topical application of fluoride-varnish was weekly administered for one month to all subjects.
Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with the Host Cell.
Cells
October 2024
Department of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy.
Article Synopsis
- * Different bacteria, including Gram-negative types and their outer membrane vesicles (OMVs), can trigger pyroptosis in various cell types, which affects inflammation and barriers in our body, but more research is needed to fully understand these effects.
- * The review will delve into how pyroptosis pathways differ between harmful and harmless bacteria, while also examining experimental models and potential treatments that target these pathways to improve infection management.
A case of Fitz-Hugh-Curtis syndrome diagnosed by noninvasive metagenomic next-generation sequencing.
Taiwan J Obstet Gynecol
November 2024
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- Fitz-Hugh-Curtis Syndrome (FHCS) is an inflammation linked to pelvic inflammatory disease caused by sexually transmitted infections, leading to symptoms like abdominal pain and possible liver capsule issues.
- A case study of a 22-year-old woman revealed her abdominal pain was misdiagnosed as advanced ovarian cancer, but mNGS testing revealed an infection with Chlamydia trachomatis in her ascitic fluid.
- The use of mNGS proved to be an effective method for diagnosing this rare condition, showing promise as a non-invasive technique for identifying pathogens with high accuracy.
Oral Microbiota Development in the First 60 Months: A Longitudinal Study.
J Dent Res
November 2024
The Lion Foundation for Dental Health, Taito-ku, Tokyo, Japan.
Childhood is considered crucial in the establishment of future oral microbiota. However, the precise period of oral microbiota development remains unclear. This study aimed to identify the progression of oral microbiota formation in children.
View Article and Find Full Text PDFMetagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda.
PLoS Negl Trop Dis
September 2024
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Article Synopsis
- Metagenomic next generation sequencing (mNGS) effectively identified novel and rare pathogens in patients with unexplained acute febrile illness in Uganda, surpassing traditional clinical microbiology methods.
- The study involved 42 participants, aged around 28, who exhibited symptoms suggestive of viral infections, with 10 of them (23.8%) showing significant viral, bacterial, or fungal signals.
- This research confirmed the presence of Rickettsia conorii, causing Mediterranean Spotted Fever, marking the first documented case in sub-Saharan Africa, highlighting the potential of mNGS for future disease surveillance.
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