AI Article Synopsis
- Marine actinomycetes, particularly the strain Streptomyces ovatisporus S4702T, are valuable for their unique bioactive compounds with antimicrobial and anti-cancer properties.
- The study aimed to explore the bioactive potential of this marine-derived strain by culturing it and extracting compounds using various organic solvents, followed by detailed chemical characterization and biological testing.
- The results showed that an ethyl acetate extract was highly effective against specific bacteria (Bacillus subtilis and Micrococcus luteus) and revealed a promising compound with significant antibacterial and cytotoxic activity, making it a viable candidate for medicinal applications.
Article Abstract
Background: Marine actinomycetes are among indispensable sources of natural bioactive compounds with unique antimicrobial and anti-cancer activities.
Objective: Herein, it was aimed to elucidate the bioactive potential of a marine-derived Streptomyces ovatisporus S4702T, isolated previously.
Methods: Streptomyces ovatisporus S4702 was cultured in N-Z Amine broth, and extraction was carried out using different organic solvents. Bioassay-guided purification was followed by chemical characterization using NMR and LC-MS/MS. The compound was then evaluated for its antibacterial, antioxidant and cytotoxic activities.
Results: Etyl acetate extracts gave the highest antibacterial activity, and chemical characterization of this extract indicated the formula as C15H29O5N3 and the corresponding possible molecular structure as 4H-chromen-4-one derivative. It was found highly potent against Bacillus subtilis ATCC 6633 (MIC: 0.25 μg ml) and Micrococcus luteus ATCC 9341 (MBC: 0.5 μg ml). It has no remarkable antioxidant activity, but a higher EC50 value and less cytotoxicity against normal cells. The EC50 values of this chromen derivative were found as 9.68 μg ml-1 for human colon carcinoma, 9.93 μg ml for human prostate adenocarcinoma and 25.5 μg ml for human embryonic kidney cells.
Conclusion: Overall, the presented 4H-chromen-4-one derivative is a remarkable bioactive compound with potent antibacterial and cytotoxic activity. With its high bioactive potential, it is proposed as a good candidate in medicine.
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| http://dx.doi.org/10.2174/1871520621666210311085748 | DOI Listing |
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