Two previously undescribed triterpenoids (), along with thirteen known compounds () were isolated from a CHCl-soluble extract of the leaves of . Their structures were established on the basis of chemical and spectroscopic approaches. These compounds were assessed for their therapeutic effects on diabetic nephropathy (DN)-evoked fibrosis through High-Glucose and transforming growth factor-β1 (TGF-β1) challenged HK-2 cells. Among them, compounds , and could remarkedly decrease the level of fibronectin to relieve DN with 27.66 ± 2.77%, 6.09 ± 0.57% and 17.74 ± 5.83% inhibition rate at 10 μM, 10 μM and 1 μM, respectively.
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| http://dx.doi.org/10.1080/14786419.2021.1900845 | DOI Listing |
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