In recent years, tissue engineering approaches have attracted substantial attention owing to their ability to create physiologically relevant disease models that closely mimic conditions. Here, we review nanocomposite materials and scaffolds used for the design of models of cancer, including metastatic sites. We discuss the role of material properties in modulating cellular phenotype in 3D disease models. Also, we highlight the application of tissue-engineered bone as a tool for faithful recapitulation of the microenvironment of metastatic prostate and breast cancer, since these two types of cancer have the propensity to metastasize to bone. Overall, we summarize recent efforts on developing 3D models of bone metastatic cancers that provide a platform to study tumor progression and facilitate high-throughput drug screening.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948119 | PMC |
| http://dx.doi.org/10.1016/j.cobme.2020.100254 | DOI Listing |
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