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Antigenic operon fragmentation and diversification mechanism in impacts gut metagenomics and pathobionts in Crohn's disease microlesions.
Gut Microbes
June 2024
Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Comensal () and are often linked to gut inflammation. However, the causes for variability of pro-inflammatory surface antigens that affect gut commensal/opportunistic dualism in remain unclear. By using the classical lipopolysaccharide/O-antigen ' operon' in as a surface antigen model (5-gene-cluster ), and a recent typing strategy for strain classification, we characterized the integrity and conservancy of the entire operon in .
View Article and Find Full Text PDFThe basis of antigenic operon fragmentation in and commensalism.
bioRxiv
June 2023
Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
The causes for variability of pro-inflammatory surface antigens that affect gut commensal/opportunistic dualism within the phylum remain unclear (1, 2). Using the classical lipopolysaccharide/O-antigen ' operon' in as a surface antigen model (5-gene-cluster ), and a recent typing strategy for strain classification (3), we characterized the architecture/conservancy of the entire operon in . Analyzing complete genomes, we discovered that most have the operon fragmented into non-random gene-singlets and/or doublets/triplets, termed 'minioperons'.
View Article and Find Full Text PDFBacteremia caused by Alistipes finegoldii in a patient with peritonitis.
Enferm Infecc Microbiol Clin (Engl Ed)
February 2023
Servicio de Microbiología e Instituto de Investigación Biosanitaria ibs.GRANADA, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Effects of Fucoidan Isolated From on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
Front Immunol
June 2022
Department of Aquaculture, Zhejiang Ocean University, Zhoushan, China.
The effects of fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of and , and inhibiting , , , , and .
View Article and Find Full Text PDFPeritonitis due to Alistipes finegoldii in a patient on peritoneal dialysis.
Ther Apher Dial
December 2021
Unit of Peritoneal Dialysis, Hospital Txagorritxu, Vitoria-Gasteiz, Spain.
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