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- The Da Vinci robotic platforms have evolved significantly over the last two decades, leading to advancements in surgical techniques and technology used in robotic-assisted surgery, including the introduction of the new Da Vinci 5 model.
- A video compilation was created to compare the Da Vinci 5 and Da Vinci Xi during radical prostatectomy, highlighting the technical improvements and modifications of the new platform.
- The surgical technique remains consistent with previous approaches, emphasizing the steps involved in a radical prostatectomy using the Da Vinci 5, such as anterior bladder neck access and posterior dissection.
Unusual metallic state in superconducting A15-type LaH.
Natl Sci Rev
December 2024
State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, China.
Hydride superconductors continue to fascinate the communities of condensed matter physics and material scientists because they host the promising near room-temperature superconductivity. Current research has concentrated on the new hydride superconductors with the enhancement of the superconducting transition temperature ( ). The multiple extreme conditions (high pressure/temperature and magnetic field) will introduce new insights into hydride superconductors.
View Article and Find Full Text PDFParticle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.
Int J Part Ther
September 2024
Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities.
View Article and Find Full Text PDFCross-disciplinary advance care planning in oncology and palliative care amidst a pandemic: a best practice implementation project.
JBI Evid Implement
November 2024
Evidence-Based Practice in Brandenburg: A JBI Affiliated Group, Brandenburg Medical School Theodor Fontane, Rüdersdorf, Germany.
Introduction: Advance care planning (ACP) ensures that patients receive medical care aligned with their values, goals, and preferences, especially regarding end-of-life decisions in serious chronic illnesses.
Objective: This project aimed to introduce and promote evidence-based ACP in oncology and palliative care at a midsized hospital near Berlin, Germany, during the COVID-19 pandemic.
Methods: This project was guided by the JBI Evidence Implementation Framework and used a mixed methods audit cycle.
Esterification of Cyclic N-Threonylcarbamoyladenosine During RNA Sample Preparation.
ChemMedChem
July 2024
Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128, Mainz, Germany.
The continuous deciphering of crucial biological roles of RNA modifications and their involvement in various pathological conditions, together with their key roles in the use of RNA-based therapeutics, has reignited interest in studying the occurrence and identity of non-canonical ribonucleoside structures during the past years. Discovery and structural elucidation of new modified structures is usually achieved by combination of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) at the nucleoside level and stable isotope labeling experiments. This approach, however, has its pitfalls as demonstrated in the course of the present study: we structurally elucidated a new nucleoside structure that showed significant similarities to the family of (c)tA modifications and was initially considered a genuine modification, but subsequently turned out to be an in vitro formed glycerol ester of tA.
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